正常人类细胞中紫外线照射的人巨细胞病毒的增强再激活与诱变之间的关系。
Relationship between enhanced reactivation and mutagenesis of u.v.-irradiated human cytomegalovirus in normal human cells.
作者信息
Dion M, Hamelin C
出版信息
EMBO J. 1987 Feb;6(2):397-9. doi: 10.1002/j.1460-2075.1987.tb04768.x.
Abstract
The survival of u.v.-irradiated human cytomegalovirus (HCMV) on u.v.-irradiated human IAFP-1 cells was increased over that on unirradiated cells. Irradiated virus had a higher forward mutation frequency towards temperature sensitivity in irradiated than in unirradiated cells. Enhanced reactivation of u.v.-irradiated HCMV is thus mutagenic in normal human cells. This observation supports the possible induction of an error-prone mode of DNA repair in u.v.-irradiated mammalian cells.
摘要
紫外线照射的人巨细胞病毒（HCMV）在紫外线照射的人IAFP-1细胞上的存活率高于未照射细胞。与未照射细胞相比，照射后的病毒在照射细胞中对温度敏感性的正向突变频率更高。因此，紫外线照射的HCMV的增强再激活在正常人细胞中具有致突变性。这一观察结果支持了紫外线照射的哺乳动物细胞中可能诱导出易出错的DNA修复模式。
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