Mironova Yu S, Zhukova I A, Zhukova N G, Alifirova V M, Izhboldina O P, Latypova A V
Siberian State Medical University, Tomsk, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6. Vyp. 2):50-54. doi: 10.17116/jnevro201811806250.
To measure the concentration of glutamate in the serum of patients with Parkinson's disease (PD) and determine its association with clinical variants of disease course.
One hundred and ten patients with PD and 90 healthy people were examined. Glutamate concentration in the blood serum was determined with a spectrophotometric method.
Patients with Parkinson's disease had significantly higher levels of serum glutamate compared with healthy subjects (p<0,0001). Patients with a tremor-dominant subtype had significantly higher levels of serum glutamate compared to those in patients with akinetic-rigid and mixed subtypes. The results obtained allow us to expand our understanding of the pathogenesis of this disease. Changes in the concentration of glutamate may reflect neurodegenerative process in PD.
测量帕金森病（PD）患者血清中谷氨酸的浓度，并确定其与疾病病程临床变异的关联。
对110例帕金森病患者和90名健康人进行了检查。采用分光光度法测定血清中谷氨酸的浓度。
与健康受试者相比，帕金森病患者血清谷氨酸水平显著更高（p<0.0001）。震颤为主型亚型患者的血清谷氨酸水平显著高于运动不能-强直型和混合型亚型患者。所获得的结果使我们能够扩展对该疾病发病机制的理解。谷氨酸浓度的变化可能反映帕金森病中的神经退行性过程。
