Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences , The University of Tokyo , Bunkyo-ku, Tokyo 113-8657 , Japan.
National Research Institute of Fisheries Science , 2-12-4 Fukuura , Kanazawa, Yokohama 236-8648 , Japan.
J Nat Prod. 2018 Nov 26;81(11):2595-2599. doi: 10.1021/acs.jnatprod.8b00591. Epub 2018 Oct 22.
There are several examples of marine organisms whose metabolic profiles differ among conspecifics inhabiting the same region. We have analyzed the metabolic profile of each colony of a Theonella swinhoei marine sponge with a yellow interior and noticed the patchy distribution of one metabolite. This compound was isolated and its structure was studied by a combination of spectrometric analyses and chemical degradation, showing it to be a congener in the theonellamide class of bicyclic peptides. Theonellamides had previously been isolated by us only from T. swinhoei with a white interior and not from those with a yellow interior.
有几种海洋生物的代谢特征在同一地区的同种生物之间存在差异。我们分析了黄色内部的团皮海绵（Theonella swinhoei）的每个殖民地的代谢特征，并注意到一种代谢物的分布不均匀。这种化合物被分离出来，并通过光谱分析和化学降解的组合研究其结构，表明它是双环肽中的同类物。我们之前仅从内部为白色的团皮海绵（Theonella swinhoei）中分离出过这类物质，而从未从内部为黄色的海绵中分离出过。
