保尔托利德斯 A--C，来自帕劳海绵 Theonella swinhoei 的 anabaenopeptin 型肽。
Paltolides A--C, anabaenopeptin-type peptides from the palau sponge Theonella swinhoei.
机构信息
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0820, USA.
出版信息
J Nat Prod. 2010 Mar 26;73(3):485-8. doi: 10.1021/np900728x.
Abstract
Three new anabaenopeptin-like peptides, named paltolides A-C, were isolated from a deep-water specimen of the marine sponge Theonella swinhoei from Palau. Paltolides belong to a rare subgroup of sponge-derived anabaenopeptins that have in common a C-terminal tryptophan residue linked to the epsilon-amine of a lysine bearing a d configuration. The structures of paltolides A-C were determined by NMR and tandem MS techniques. Paltolide A is the first anabaenopeptin structure where a non-N-methylated amino acid precedes the C-terminal residue.
摘要
三种新的 anabaenopeptin 类似肽，命名为 paltolides A-C，从帕劳海域海绵 Theonella swinhoei 的深海标本中分离得到。Paltolides 属于海绵衍生 anabaenopeptins 的一个罕见亚群，它们的共同点是 C 末端色氨酸残基与带有 d 构型的赖氨酸的 ε- 氨基相连。Paltolides A-C 的结构通过 NMR 和串联 MS 技术确定。Paltolide A 是第一个 C 末端残基前有非 N-甲基化氨基酸的 anabaenopeptin 结构。
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