School of Information Science and Engineering, Central South University, Changsha, Hunan 410083, China; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008 Hunan, China.
School of Basic Medical Science Central South University, Changsha, Hunan 410083, China.
Clin Neurophysiol. 2018 Dec;129(12):2507-2516. doi: 10.1016/j.clinph.2018.09.006. Epub 2018 Sep 24.
Our study aims to extract significant disorder-associated patterns from whole brain functional connectivity to distinguish mild-moderate Parkinson's disease (PD) patients from controls.
Resting-state fMRI data were measured from thirty-six PD individuals and thirty-five healthy controls. Multivariate pattern analysis was applied to investigate whole-brain functional connectivity patterns in individuals with 'mild-moderate' PD. Additionally, the relationship between the asymmetry of functional connectivity and the side of the initial symptoms was also analyzed.
In a leave-one-out cross-validation, we got the generalization rate of 80.28% for distinguishing PD patients from controls. The most discriminative functional connectivity was found in cortical networks that included the default mode, sensorimotor and attention networks. Compared to patients with the left side initially affected, an increased abnormal functional connectivity was found in patients in whom the right side was initially affected.
Our results indicated that discriminative functional connectivity is likely associated with disturbances of cortical networks involved in sensorimotor control and attention. The spatiotemporal patterns of motor asymmetry may be related to the lateralized dysfunction on the early stages of PD.
This study identifies discriminative functional connectivity that is associated with disturbances of cortical networks. Our results demonstrated new evidence regarding the functional brain changes related to the unilateral motor symptoms of early PD.
本研究旨在从全脑功能连接中提取出与疾病相关的显著模式，以区分轻度至中度帕金森病（PD）患者与对照组。
对 36 名 PD 患者和 35 名健康对照者进行静息态 fMRI 数据测量。采用多变量模式分析来研究“轻度至中度”PD 个体的全脑功能连接模式。此外，还分析了功能连接的不对称性与初始症状侧之间的关系。
在一次留一交叉验证中，我们得到了 80.28%的区分 PD 患者与对照组的泛化率。在区分 PD 患者与对照组时，最具判别力的功能连接位于包括默认模式、感觉运动和注意力网络在内的皮质网络中。与左侧初始受累的患者相比，右侧初始受累的患者中发现了异常功能连接增加。
我们的结果表明，具有判别力的功能连接可能与涉及感觉运动控制和注意力的皮质网络的紊乱有关。运动不对称的时空模式可能与 PD 早期的偏侧功能障碍有关。
本研究确定了与皮质网络紊乱相关的具有判别力的功能连接。我们的结果提供了与早期 PD 单侧运动症状相关的功能性脑变化的新证据。
