Li Kai, Su Wen, Chen Min, Li Chun-Mei, Ma Xin-Xin, Wang Rui, Lou Bao-Hui, Zhao Hong, Chen Hai-Bo, Yan Chuan-Zhu
Department of Neurology, National Center of Gerontology, Beijing Hospital, Beijing, China.
Department of Neurology, Research Institute of Neuromuscular and Neurodegenerative Disease, Qilu Hospital of Shandong University, Jinan, China.
Front Neurol. 2020 Jul 28;11:727. doi: 10.3389/fneur.2020.00727. eCollection 2020.
Motor asymmetry is characteristic in Parkinson disease (PD). This phenomenon is originated from uneven degeneration of bilateral substantia nigra. However, this asymmetry may not restrict to substantia nigra or striatum. We aimed to determine the effect of asymmetry on spontaneous brain activity across the whole brain. We consecutively recruited 71 patients with PD, as well as 35 healthy controls, and collected relevant demographic, clinical, and neuropsychological information. The PD patients were divided into two groups according to the side of motor symptom onset. All the participants underwent resting-state functional magnetic resonance imaging, and spontaneous brain activity was assessed using amplitude of low-frequency fluctuation (ALFF). The associations between areas showing significant group differences and various clinical and neuropsychological measures were analyzed. Finally, the data of 30 PD patients with left-onset (LPD), 27 PD patients with right-onset (RPD), and 32 healthy controls were obtained. The three groups had similar age and gender ratios. Our results demonstrated that LPD patients had increased ALFF in the left inferior temporal gyrus and decreased ALFF in bilateral thalamus and cerebellum anterior lobes than the control group. The value of ALFF of the left inferior temporal gyrus was correlated with motor function, and ALFF value of the thalamus was associated with cognition. Comparisons between LPD and RPD patients and between RPD patients and the controls did not yield significant difference. The present study provides new insights into the distinct characteristics of spontaneous brain activity in LPD, which may be associated with motor and cognitive function.
运动不对称是帕金森病（PD）的特征。这种现象源于双侧黑质的不均衡退化。然而，这种不对称可能并不局限于黑质或纹状体。我们旨在确定不对称对全脑自发脑活动的影响。我们连续招募了71例PD患者以及35名健康对照者，并收集了相关的人口统计学、临床和神经心理学信息。根据运动症状发作的侧别将PD患者分为两组。所有参与者均接受静息态功能磁共振成像检查，并使用低频振幅（ALFF）评估自发脑活动。分析显示出显著组间差异的区域与各种临床和神经心理学指标之间的关联。最后，获得了30例左侧发病的PD患者（LPD）、27例右侧发病的PD患者（RPD）和32名健康对照者的数据。三组的年龄和性别比例相似。我们的结果表明，与对照组相比，LPD患者左侧颞下回的ALFF增加，双侧丘脑和小脑前叶的ALFF降低。左侧颞下回的ALFF值与运动功能相关，丘脑的ALFF值与认知相关。LPD与RPD患者之间以及RPD患者与对照组之间的比较未产生显著差异。本研究为LPD患者自发脑活动的独特特征提供了新的见解，这可能与运动和认知功能有关。
