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单纯疱疹病毒无症状排毒及后续传播

Asymptomatic shedding and subsequent transmission of genital herpes simplex virus.

作者信息

Barton S E, Davis J M, Moss V W, Tyms A S, Munday P E

出版信息

Genitourin Med. 1987 Apr;63(2):102-5. doi: 10.1136/sti.63.2.102.

DOI:10.1136/sti.63.2.102
PMID:3034759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1194027/
Abstract

We report the transmission of genital herpes simplex virus (HSV) infection from an asymptomatic woman shedding virus from the cervix to two male sexual partners and further transmission from these two men while their infection was in the prodromal phase. The value of the restriction enzyme analysis of viral deoxyribonucleic acid (DNA) is presented. Guidelines regarding the management of patients who are found to be asymptomatic shedders of HSV are discussed.

摘要

我们报告了一例单纯疱疹病毒（HSV）生殖器感染的传播情况，一名宫颈无症状排毒的女性将病毒传染给了两名男性性伴侣，而这两名男性在感染前驱期又发生了进一步传播。文中介绍了病毒脱氧核糖核酸（DNA）限制性内切酶分析的价值。还讨论了关于对被发现为HSV无症状排毒者的患者的管理指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a1/1194027/62e563429210/genitmed00062-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a1/1194027/62e563429210/genitmed00062-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12a1/1194027/62e563429210/genitmed00062-0034-a.jpg

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Asymptomatic shedding and subsequent transmission of genital herpes simplex virus.单纯疱疹病毒无症状排毒及后续传播
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J Clin Microbiol. 2005 May;43(5):2173-80. doi: 10.1128/JCM.43.5.2173-2180.2005.
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Civamide (cis-capsaicin) for treatment of primary or recurrent experimental genital herpes.辣椒酰胺（顺式辣椒素）用于治疗原发性或复发性实验性生殖器疱疹。
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Genital herpes, "the new paradigm".

本文引用的文献

1
Suppression of frequently recurring genital herpes. A placebo-controlled double-blind trial of oral acyclovir.复发性生殖器疱疹的抑制作用。口服阿昔洛韦的安慰剂对照双盲试验。
N Engl J Med. 1984 Jun 14;310(24):1545-50. doi: 10.1056/NEJM198406143102401.
2
Bam HI characterization of 15 HSV-DNAs isolated from recrudescent lesions of three individuals.
Microbiologica. 1984 Jan;7(1):85-90.
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Reinfection is an uncommon occurrence in patients with symptomatic recurrent genital herpes.对于有症状的复发性生殖器疱疹患者，再次感染是一种不常见的情况。
生殖器疱疹，“新范式”。
J Clin Pathol. 1999 Jan;52(1):1-4. doi: 10.1136/jcp.52.1.1.
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Genital herpes: review of the epidemic and potential use of type-specific serology.生殖器疱疹：流行病学综述及型特异性血清学的潜在应用
Clin Microbiol Rev. 1999 Jan;12(1):1-8. doi: 10.1128/CMR.12.1.1.
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Premarket evaluation of a commercial glycoprotein G-based enzyme immunoassay for herpes simplex virus type-specific antibodies.一种基于糖蛋白G的用于单纯疱疹病毒型特异性抗体的商业酶免疫测定法的上市前评估。
J Clin Microbiol. 1998 Jan;36(1):294-5. doi: 10.1128/JCM.36.1.294-295.1998.
6
Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment.免疫功能正常女性频繁单纯疱疹病毒2型排毒。阿昔洛韦治疗的效果。
J Clin Invest. 1997 Mar 1;99(5):1092-7. doi: 10.1172/JCI119237.
7
Vagina dentata revisited: gender and asymptomatic shedding of genital herpes.重探阴道齿状：性别与生殖器疱疹的无症状排毒
Cult Med Psychiatry. 1995 Dec;19(4):479-501. doi: 10.1007/BF01379399.
8
Laboratory techniques in the diagnosis of herpes simplex infection.单纯疱疹感染诊断中的实验室技术
Genitourin Med. 1993 Jun;69(3):174-83. doi: 10.1136/sti.69.3.174.
9
Psychosocial implications of recurrent genital herpes simplex virus infection.复发性生殖器单纯疱疹病毒感染的心理社会影响。
Genitourin Med. 1988 Oct;64(5):327-30. doi: 10.1136/sti.64.5.327.
10
Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes.女性首次发生生殖器疱疹后单纯疱疹病毒的无症状再激活。
Ann Intern Med. 1992 Mar 15;116(6):433-7. doi: 10.7326/0003-4819-116-6-433.
J Infect Dis. 1984 Apr;149(4):645-6. doi: 10.1093/infdis/149.4.645.
4
Restriction endonuclease patterns of herpes simplex virus DNA: application to diagnosis and molecular epidemiology.单纯疱疹病毒DNA的限制性内切酶图谱：在诊断和分子流行病学中的应用。
Curr Top Microbiol Immunol. 1983;104:273-86. doi: 10.1007/978-3-642-68949-9_17.
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J Gen Virol. 1981 Aug;55(Pt 2):315-31. doi: 10.1099/0022-1317-55-2-315.
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N Engl J Med. 1981 Aug 6;305(6):315-9. doi: 10.1056/NEJM198108063050604.
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J Virol. 1984 Oct;52(1):300-5. doi: 10.1128/JVI.52.1.300-305.1984.