Ito M, Ishida E, Tanabe F, Shigeta S, Watanabe Y, Kawade Y
Immunology. 1987 Apr;60(4):617-9.
Murine peritoneal macrophages pretreated with interferon (IFN)-alpha and then stimulated by opsonized zymosan produced two to three times more LTB4 than untreated macrophages. However, PGE2 production was not changed by IFN-alpha. Meanwhile, IFN-gamma did not affect the production of LTB4 and PGE2. From the results it is considered that IFN-alpha can modulate inflammation or host defence through the production of LTB4.
用干扰素（IFN）-α预处理的小鼠腹腔巨噬细胞，随后经调理素化酵母聚糖刺激后，产生的白三烯B4（LTB4）比未处理的巨噬细胞多两到三倍。然而，IFN-α并未改变前列腺素E2（PGE2）的产生。同时，IFN-γ不影响LTB4和PGE2的产生。从这些结果可以认为，IFN-α可通过LTB4的产生来调节炎症或宿主防御。
