在液相和超临界流体色谱中实现生物活性化合物的超快速、高通量对映体分离的方法。
The Way to Ultrafast, High-Throughput Enantioseparations of Bioactive Compounds in Liquid and Supercritical Fluid Chromatography.
机构信息
Department of Drug Chemistry and Technology, "Sapienza" University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.
Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, via L. Borsari 46, 44121 Ferrara, Italy.
出版信息
Molecules. 2018 Oct 20;23(10):2709. doi: 10.3390/molecules23102709.
Until less than 10 years ago, chiral separations were carried out with columns packed with 5 or 3 μ m fully porous particles (FPPs). Times to resolve enantiomeric mixtures were easily larger than 30 min, or so. Pushed especially by stringent requirements from medicinal and pharmaceutical industries, during the last years the field of chiral separations by liquid chromatography has undergone what can be defined a "true revolution". With the purpose of developing ever faster and efficient method of separations, indeed, very efficient particle formats, such as superficially porous particles (SPPs) or.
直到不到 10 年前，手性分离还是采用填充有 5 或 3μm 全多孔颗粒（FPP）的柱子进行的。解析对映体混合物的时间很容易超过 30 分钟。特别是受到医药行业严格要求的推动，在过去的几年中，液相色谱手性分离领域经历了一场可以被定义为“真正的革命”。为了开发更快、更有效的分离方法，实际上，出现了非常高效的颗粒形式，如表面多孔颗粒（SPPs）或。
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