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[宝藿苷Ⅰ的制备方法及药理作用]

[Preparation method and pharmacological effect of baohuoside Ⅰ].

作者信息

Li Zi-Hao, Ke Zhong-Cheng, Feng Liang, Jia Xiao-Bin

机构信息

School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2018 Sep;43(17):3444-3450. doi: 10.19540/j.cnki.cjcmm.20180702.007.

Abstract

Epimedii Folium, a famous traditional Chinese medicine made of dried leaves of Epimedium brevicomu, E. pubescens, E. sagittatum or E. koreanum, has been applied in China for several thousand years as a medicine. It has the function of reinforcing kidney Yang, strengthening muscles and bones and dispelling rheumatism. Modern studies have shown that baohuoside Ⅰ has a low content in Herba Epimedii, but it has a wide range of pharmacological effects, such as anti-osteoporosis, anti-tumor, improving cognitive dysfunction, cerebral ischemia-reperfusion injury protection, and neuroprotection. More and more attention has been paid to the preparation methods and pharmacological effects of baohuoside Ⅰ due to its many biological activities and pharmacological effects. In this present research, in order to provide references for the better mass preparation and rational exploitation of baohuoside Ⅰ, we summarized and sorted out the preparation methods and pharmacological effects of baohuoside Ⅰ which were published in recent years.

摘要

淫羊藿叶是一种著名的传统中药,由箭叶淫羊藿、柔毛淫羊藿、朝鲜淫羊藿或巫山淫羊藿的干燥叶制成,在中国作为药物应用已有数千年历史。它具有补肾阳、强筋骨、祛风湿的功效。现代研究表明,淫羊藿苷Ⅰ在淫羊藿药材中的含量较低,但具有广泛的药理作用,如抗骨质疏松、抗肿瘤、改善认知功能障碍、保护脑缺血再灌注损伤以及神经保护等。由于淫羊藿苷Ⅰ具有多种生物活性和药理作用,其制备方法和药理作用越来越受到关注。在本研究中,为了为淫羊藿苷Ⅰ的更好规模化制备和合理开发提供参考,我们对近年来发表的淫羊藿苷Ⅰ的制备方法和药理作用进行了总结和梳理。

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