Yamasaki Takahisa, Hemond Colin, Eisa Mohamed, Ganocy Stephen, Fass Ronnie
The Esophageal and Swallowing Center, Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
J Neurogastroenterol Motil. 2018 Oct 1;24(4):559-569. doi: 10.5056/jnm18140.
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is a common disease globally with increasing prevalence and consequently greater burden on the Healthcare system. Traditionally, GERD has been considered a disease of middle-aged and older people. Since risk factors for GERD affect a growing number of the adult population, concerns have been raised that increasingly younger people may develop GERD. We aim to determine if the proportion of younger patients has increased among the GERD population.
The incidence of GERD as well as several variables were evaluated during an 11-year period. Explorys was used to evaluate datasets at a "Universal" and Healthcare system in northern Ohio to determine if trends at a local level reflected those at a universal level. GERD patients were classified into 7 age groups (15-19, 20-29, 30-39, 40-49, 50-59, 60-69, and ≥ 70 years).
The proportion of patients with GERD increased in all age groups, except for those who were ≥ 70 years in the universal dataset ( < 0.001) and those who were ≥ 60 years in the Healthcare system ( < 0.001). The greatest rise was seen in 30-39 years in both datasets ( < 0.001). Similarly, the proportion of GERD patients who were using proton pump inhibitors increased in all age groups except for those who were ≥ 70 years in both datasets ( < 0.001), with the greatest increase being the group 30-39 years ( < 0.001).
Over the last decade, there has been a significant increase in the proportion of younger patients with GERD, especially those within the age range of 30-39 years.
背景/目的：胃食管反流病（GERD）是一种全球常见疾病，其患病率不断上升，给医疗系统带来了更大负担。传统上，GERD被认为是中老年人的疾病。由于GERD的危险因素影响着越来越多的成年人群，人们担心越来越年轻的人可能会患上GERD。我们旨在确定GERD患者中年轻患者的比例是否有所增加。
在11年期间评估了GERD的发病率以及几个变量。利用Explorys评估俄亥俄州北部一个“通用”医疗系统的数据，以确定地方层面的趋势是否反映了通用层面的趋势。GERD患者被分为7个年龄组（15 - 19岁、20 - 29岁、30 - 39岁、40 - 49岁、50 - 59岁、60 - 69岁和≥70岁）。
除了通用数据集中≥70岁的患者（<0.001）和医疗系统中≥60岁的患者（<0.001）外，所有年龄组的GERD患者比例均有所增加。两个数据集中30 - 39岁组的增幅最大（<0.001）。同样，除了两个数据集中≥70岁的患者外，所有年龄组中使用质子泵抑制剂的GERD患者比例均有所增加（<0.001），增幅最大的是30 - 39岁组（<0.001）。
在过去十年中，GERD年轻患者的比例显著增加，尤其是年龄在30 - 39岁之间的患者。
