Division of Gastroenterology and Hepatology, MetroHealth Medical Center, The Esophageal and Swallowing Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Esophagus. 2020 Apr;17(2):190-196. doi: 10.1007/s10388-019-00707-7. Epub 2020 Jan 1.
Barrett's esophagus (BE), a complication of long-term gastroesophageal reflux disease (GERD), has been reported to affect 6-8% of those with heartburn. Most patients are males, Caucasians and middle aged. However, there are no recent demographic studies that evaluated the proportion trends of BE. We aimed to assess proportion trends of BE over an 11-year period, using a very large national dataset.
This was a population-based analysis of the national Explorys dataset. Explorys is an aggregate of electronic medical record database representing over 54 million patients. Proportions of BE's variables such as age, gender, race, BMI, and treatment with PPI were recorded during an 11-year period. BE patients were classified into seven age groups (15-19, 20-29, 30-39, 40-49, 50-59, 60-69, ≥ 70 years old). Secular trends of the proportion of BE were assessed over time for each age group.
The majority of patients diagnosed with BE were ≥ 70 years old across all calendar years. However, the proportion of BE patients who were ≥ 70 years old has significantly decreased between 2006 and 2016 (- 19.9%, p < 0.001). The proportion of patients with BE increased in all age groups but most prominently in the age groups, 30-39: 2.07%, 40-49: 3.64%, 50-59: 6.89%, 60-69: 6.18%, p < 0.001. BE was significantly more common in those who were Caucasian and male. PPI usage fell significantly in those who were ≥ 70 years old (- 20.8%, p < 0.001), but increased in the other remaining age groups.
The proportion of BE patients who are 70 years and older has significantly dropped. Younger patients' groups have demonstrated the highest increase in the proportion of BE patients, especially those in the age group of 30-39 years old.
巴雷特食管（BE）是长期胃食管反流病（GERD）的并发症，据报道，6-8%的烧心患者会出现这种情况。大多数患者为男性、白种人和中年人群。然而，目前尚无最新的人口统计学研究评估 BE 的比例趋势。我们旨在使用一个非常大的全国性数据集评估 11 年间 BE 的比例趋势。
这是对全国性 Explorys 数据集的基于人群的分析。Explorys 是一个代表超过 5400 万患者的电子病历数据库的集合。在 11 年期间记录了 BE 的变量，如年龄、性别、种族、BMI 和 PPI 治疗的比例。BE 患者被分为七个年龄组（15-19、20-29、30-39、40-49、50-59、60-69、≥70 岁）。评估了每个年龄组随时间推移的 BE 比例的长期趋势。
在所有日历年内，被诊断为 BE 的大多数患者都≥70 岁。然而，2006 年至 2016 年间，≥70 岁的 BE 患者比例显著下降（-19.9%，p<0.001）。所有年龄组的 BE 患者比例均有所增加，但在 30-39 岁、40-49 岁、50-59 岁、60-69 岁年龄组最为明显：2.07%、3.64%、6.89%、6.18%，p<0.001。BE 在白人和男性中更为常见。≥70 岁的患者中 PPI 的使用显著下降（-20.8%，p<0.001），但在其他年龄组中则增加。
70 岁及以上的 BE 患者比例显著下降。年轻患者组的 BE 患者比例增长最高，尤其是 30-39 岁年龄组。
