Abdou Asmaa Gaber, Maraee Alaa, Yassien Hossam, Sarhan Mona
Department of Pathology, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt.
Department of Dermatology, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt.
J Pathol Transl Med. 2018 Nov;52(6):363-368. doi: 10.4132/jptm.2018.09.18. Epub 2018 Oct 23.
Vitiligo is a chronic autoimmune disease in which the destruction of melanocytes causes white spots on the affected skin. Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-signal transducer and activator of transcription pathway. The aim of the present study is to explore the possible role of JAK1 in the pathogenesis of vitiligo using immunohistochemical methods.
The current study was conducted in a sample of 39 patients who presented with vitiligo and 22 healthy individuals who were age and sex matched as a control group. We used immunohistochemistry to evaluate JAK1 status (intensity and distribution) and assess the percentage of residual melanocytes using human melanoma black 45 (HMB45).
Intense and diffuse JAK1 expression was significantly more likely to indicate vitiliginous skin compared to normal skin (p < .001). Strong and diffuse JAK1 expression was associated with short disease duration, female sex, and lower percentage of melanocytes (detected by HMB45) (p < .05).
JAK1 may be involved in the pathogenesis of vitiligo, as indicated by intense and diffuse expression compared to control and association with lower percentage of melanocytes detected by HMB45 immunostaining.
白癜风是一种慢性自身免疫性疾病，其中黑素细胞的破坏导致受影响皮肤出现白斑。Janus激酶（JAK）是一类细胞内非受体酪氨酸激酶家族，其通过JAK-信号转导子和转录激活子途径转导细胞因子介导的信号。本研究的目的是使用免疫组织化学方法探讨JAK1在白癜风发病机制中的可能作用。
本研究纳入了39例白癜风患者作为样本，并选取22例年龄和性别匹配的健康个体作为对照组。我们使用免疫组织化学评估JAK1状态（强度和分布），并使用人黑素瘤黑色45（HMB45）评估残余黑素细胞的百分比。
与正常皮肤相比，强烈且弥漫的JAK1表达更有可能提示白癜风皮肤（p <.001）。强烈且弥漫的JAK1表达与病程短、女性以及较低的黑素细胞百分比（通过HMB45检测）相关（p <.05）。
与对照组相比，JAK1的强烈且弥漫表达以及与HMB45免疫染色检测到的较低黑素细胞百分比相关，提示JAK1可能参与白癜风的发病机制。
