1 Institute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany.
2 Inserm CIC1415, CHRU de Tours, Tours, France.
Cephalalgia. 2019 May;39(6):711-721. doi: 10.1177/0333102418804155. Epub 2018 Oct 22.
The aim was to evaluate the association of self-perceived levels of attention deficit and hyperactivity symptoms with non-migraine and migraine headaches among university students. We also evaluated their association with migraine aura.
Study subjects were all participants in the internet-based Students Health Research Enterprise. Scores were built to evaluate global attention and hyperactivity symptom levels, self-perceived attention deficit levels and self-perceived hyperactivity symptom levels based on the Adult Attention Deficit and Hyperactivity Disorder Self-Report Scale (ASRS v1.1.). We used standardised questions to classify headache and group participants into "no headache," "non-migraine headache," "migraine without aura" or "migraine with aura".
A total of 4816 students were included (mean age 20.3 ± 2.8 years; 75.5% women). Compared with participants without headache, we found significant associations between global ADHD scores and migraine. Students in the highest quintile of global ASRS scores had adjusted odds ratio (aOR) of 1.95 (95% CI 1.56-2.45) when compared to the lowest. This association was mainly driven by an association between self-perceived hyperactivity and migraine with aura. The aOR for migraine with aura was 2.83 (95% CI 2.23-3.61) for students in the highest quintile of hyperactivity. No significant association was found for any attention and hyperactivity symptom level measure and non-migraine headache and between self-perceived levels of attention deficit and migraine.
Among students in higher education in France, self-perceived levels of attention deficit and hyperactivity symptoms were selectively associated with migraine. The association was strongest for the hyperactivity domain and migraine with aura.
评估大学生自我感知的注意力缺陷和多动症状水平与非偏头痛和偏头痛头痛之间的关系。我们还评估了它们与偏头痛先兆之间的关系。
研究对象均为基于互联网的学生健康研究企业的参与者。根据成人注意力缺陷多动障碍自评量表（ASRS v1.1.），建立了评估总体注意力和多动症状水平、自我感知注意力缺陷水平和自我感知多动症状水平的评分。我们使用标准化问题将头痛分类，并将参与者分为“无头痛”、“非偏头痛头痛”、“无先兆偏头痛”或“有先兆偏头痛”。
共纳入 4816 名学生（平均年龄 20.3±2.8 岁；75.5%为女性）。与无头痛的参与者相比，我们发现总体 ADHD 评分与偏头痛之间存在显著关联。与最低五分位相比，全球 ASRS 评分最高五分位的学生调整后的优势比（aOR）为 1.95（95%CI 1.56-2.45）。这种关联主要是由自我感知的多动与有先兆偏头痛之间的关联驱动的。在多动评分最高五分位的学生中，有先兆偏头痛的 aOR 为 2.83（95%CI 2.23-3.61）。任何注意力和多动症状水平测量与非偏头痛头痛以及自我感知的注意力缺陷与偏头痛之间均无显著关联。
在法国高等教育的学生中，自我感知的注意力缺陷和多动症状与偏头痛有选择性关联。这种关联在多动领域和有先兆偏头痛中最强。
