Belayneh Yaschilal Muche, Amberbir Gedefaye, Agalu Asrat
Department of Pharmacy, College of medicine and Health Sciences, Wollo University, P.O. Box 1145, Dessie, Ethiopia.
BMC Health Serv Res. 2018 Oct 22;18(1):808. doi: 10.1186/s12913-018-3612-x.
Drug therapy problem is any undesirable event experienced by a patient during drug therapy that interferes with achieving the desired goals of therapy. Drug therapy problems are common causes of patient morbidity and mortality. There was no study that has been done on drug therapy problems in the study area, Dessie referral hospital, northeast Ethiopia.
A prospective observational study was conducted among hospitalized patients in the medical ward of Dessie referral hospital from March 01 to May 31, 2014. Ethical approval was obtained and informed consent was signed by each study participant before the commencement of the study. All patients admitted to the ward during the study period were included in the study. Data regarding each patient's demographics, medical condition, drug therapy and patient compliance to the drug therapy were collected using pretested checklists, and drug therapy problems were determined based on the standard practice and textbooks. Descriptive statistical analysis was done using SPSS Version 20 Software.
A total of 147 patients were included, 75.51% of whom experienced at least one drug therapy problem. During the 3 month period a total of 159 drug therapy problems were identified of which needs additional drug therapy (35.85%) was the most common followed by unnecessary drug therapy (30.19%) and dosage too low (13.2%). Antibiotics, 75 (40.32%) was the most frequent drug class involved in drug therapy problems followed by cardiovascular drugs, 69 (37.1%) and nonsteroidal anti-inflammatory drugs, 9 (4.84%). Ceftriaxone (25.81%) was the most frequent specific drug prone to the drug therapy problems followed by spiranolactone (14.52%), enalapril (6.45%) and furosemide (6.45%).
Three out of four patients experienced at least one drug therapy problem during their hospital stay in the medical ward, with the most commonly observed DTP being no drug therapy prescribed for a condition requiring drug treatment.
药物治疗问题是指患者在药物治疗期间经历的任何不良事件，这些事件会干扰实现治疗的预期目标。药物治疗问题是患者发病和死亡的常见原因。在埃塞俄比亚东北部德西转诊医院这个研究区域，尚未有关于药物治疗问题的研究。
2014年3月1日至5月31日，在德西转诊医院内科病房的住院患者中进行了一项前瞻性观察研究。研究开始前获得了伦理批准，每位研究参与者签署了知情同意书。研究期间病房收治的所有患者均纳入研究。使用预先测试的检查表收集每位患者的人口统计学、医疗状况、药物治疗及患者对药物治疗的依从性数据，并根据标准做法和教科书确定药物治疗问题。使用SPSS 20版软件进行描述性统计分析。
共纳入147例患者，其中75.51%的患者至少经历了一个药物治疗问题。在这3个月期间，共识别出159个药物治疗问题，其中需要追加药物治疗（35.85%）最为常见，其次是不必要的药物治疗（30.19%）和剂量过低（13.2%）。抗生素（75种，40.32%）是药物治疗问题中涉及最频繁的药物类别，其次是心血管药物（69种，37.1%）和非甾体抗炎药（9种，4.84%）。头孢曲松（25.81%）是最常出现药物治疗问题的特定药物，其次是螺内酯（14.52%）、依那普利（6.45%）和呋塞米（6.45%）。
四分之三的患者在住院期间在内科病房至少经历了一个药物治疗问题，最常见的药物治疗问题是对于需要药物治疗的病情未开具药物治疗。
