埃塞俄比亚东北部凯米斯镇公共卫生机构对2型糖尿病患者随访期间药物相关问题及影响因素的回顾性研究。
A retrospective study of drug related problems and contributing factors among type 2 diabetes mellitus patients on follow up at public health institutions of kemisse town, north east Ethiopia.
作者信息
Belayneh Yaschilal Muche, Mamo Teshome, Ahmed Solomon, Kifle Zemene Demelash
机构信息
Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, P.O. Box 1145, Dessie, Ethiopia.
Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
Metabol Open. 2021 Jun 7;11:100098. doi: 10.1016/j.metop.2021.100098. eCollection 2021 Sep.
BACKGROUND
Drug related problems interfere with the desired treatment outcomes of type 2 Diabetes mellitus. This study was conducted to determine prevalence of drug related problems and associated factors among patients with type 2 Diabetes Mellitus in public health institutions of Kemisse town, northeast Ethiopia from May 01 to 30, 2019.
METHODS
Institution based retrospective cross sectional study was conducted among type 2 Diabetes Mellitus patents on follow up at public health institutions of Kemisse town, northeast Ethiopia.
RESULT
From the total of 156 patients included in the study, 126 (80.8%) patients have at least one drug related problem with a total of 149 drug related problems. The most prevalent drug related problems were need for additional drug therapy 60 (40.3%) followed by non-compliance 51 (34.2%) and unnecessary drug therapy 12 (8%). Identified causes of need for additional drug therapy were the need for prophylactic drug therapy (statins and antiplatelet), 83.3%; presence of untreated medical condition (Hypertension, diabetic nephropathy and diabetic foot ulcer), 11.7%; and the need for combination therapy for better efficacy, 5%. This study revealed that age ≥45 years (AOR = 5.59, 95% CI = 1.38-20.64, P = 0.016), presence of comorbid condition (AOR = 3.22, 95% CI = 1.75-13.47, P = 0.014 and emergency visit in the last one year (AOR = 5.08, 95% CI = 1.14-18.71, P = 0.033) were significantly associated with the occurrence of drug related problems.
CONCLUSION
A total of 149 drug related problems were identified in 80.8% of type 2 diabetes mellitus patients. The three most prevalent drug related problems were need for additional drug therapy 60 (40.3%) followed by non-compliance 51 (34.2%) and unnecessary drug therapy 12 (8%). Additionally, age ≥45 years (AOR = 5.59, P = 0.016), presence of comorbidity (AOR = 3.22, P = 0.014) and emergency visit in the last one year (AOR = 5.08, P = 0.033) were significantly associated with the occurrence of drug related problem.
背景
药物相关问题会干扰2型糖尿病的预期治疗效果。本研究旨在确定2019年5月1日至30日期间埃塞俄比亚东北部凯米斯镇公共卫生机构中2型糖尿病患者的药物相关问题患病率及相关因素。
方法
在埃塞俄比亚东北部凯米斯镇公共卫生机构对2型糖尿病患者进行基于机构的回顾性横断面研究。
结果
在纳入研究的156名患者中，126名（80.8%）患者至少有一个药物相关问题，共有149个药物相关问题。最常见的药物相关问题是需要额外药物治疗60例（40.3%），其次是不依从51例（34.2%）和不必要药物治疗12例（8%）。确定的需要额外药物治疗的原因是预防性药物治疗（他汀类药物和抗血小板药物）的需求，占83.3%；存在未治疗的疾病（高血压、糖尿病肾病和糖尿病足溃疡），占11.7%；以及为提高疗效而需要联合治疗，占5%。本研究表明，年龄≥45岁（调整后比值比[AOR]=5.59，95%置信区间[CI]=1.38-20.64，P=0.016）、存在合并症（AOR=3.22，95%CI=1.75-13.47，P=0.014）和过去一年的急诊就诊（AOR=5.08，95%CI=1.14-18.71，P=0.033）与药物相关问题的发生显著相关。
结论
在80.8%的2型糖尿病患者中总共发现了149个药物相关问题。三个最常见的药物相关问题是需要额外药物治疗60例（40.3%），其次是不依从51例（34.2%）和不必要药物治疗12例（8%）。此外，年龄≥45岁（AOR=5.59，P=0.016）、存在合并症（AOR=3.22，P=0.014）和过去一年的急诊就诊（AOR=5.08，P=0.033）与药物相关问题的发生显著相关。
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