Forget R, Lamarre Y
Hum Neurobiol. 1987;6(1):27-37.
Rapid goal-directed movements of elbow flexion were studied in normal human subjects and in patients deprived of proprioceptive and cutaneous feedback. All normal subjects showed a burst of electromyographic (EMG) activity in the extensor muscle (antagonist) that served to arrest the limb precisely in the target zone. The magnitude of this burst co-varied with the magnitude of the initial accelerating burst in the flexor muscle (agonist). In patients, there was a small decelerating burst poorly correlated with the agonist activity. All patients had difficulty to control the amplitude of their movements due to improper adjustment of the size and time of onset of the decelerating burst. It is concluded that the central nervous system can generate a sequence of commands to accelerate and decelerate a limb in the absence of peripheral feedback. However, information from the moving limb is required to adjust the magnitude and time of onset of deceleration.
对正常人类受试者以及失去本体感觉和皮肤反馈的患者进行了快速目标导向的屈肘运动研究。所有正常受试者在伸肌（拮抗剂）中均表现出一阵肌电图（EMG）活动，该活动有助于将肢体精确地停在目标区域。这一阵活动的幅度与屈肌（主动肌）中初始加速阵活动的幅度共同变化。在患者中，有一阵较小的减速阵，与主动肌活动的相关性较差。所有患者由于减速阵的大小和起始时间调整不当，难以控制其运动幅度。得出的结论是，中枢神经系统可以在没有外周反馈的情况下生成一系列命令来加速和减速肢体。然而，需要来自运动肢体的信息来调整减速的幅度和起始时间。
