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OXA-23 Is a Prevalent Mechanism Contributing to Sulbactam Resistance in Diverse Acinetobacter baumannii Clinical Strains.

作者信息

Yang Yunxing, Xu Qingye, Li Tingting, Fu Ying, Shi Yue, Lan Peng, Zhao Dongdong, Chen Qiong, Zhou Zhihui, Jiang Yan, Peleg Anton Y, Yu Yunsong

机构信息

Department of Infectious Disease, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, China.

出版信息

Antimicrob Agents Chemother. 2018 Dec 21;63(1). doi: 10.1128/AAC.01676-18. Print 2019 Jan.

DOI:10.1128/AAC.01676-18
PMID:30348663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6325231/
Abstract
摘要

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本文引用的文献

1
Molecular Epidemiology and Mechanism of Sulbactam Resistance in Acinetobacter baumannii Isolates with Diverse Genetic Backgrounds in China.中国不同遗传背景鲍曼不动杆菌分离株中舒巴坦耐药的分子流行病学和机制。
Antimicrob Agents Chemother. 2018 Feb 23;62(3). doi: 10.1128/AAC.01947-17. Print 2018 Mar.
2
The blaOXA-23-associated transposons in the genome of Acinetobacter spp. represent an epidemiological situation of the species encountering carbapenems.blaOXA-23 相关转座子存在于不动杆菌属基因组中，代表了该物种遭遇碳青霉烯类抗生素的流行病学情况。
J Antimicrob Chemother. 2017 Oct 1;72(10):2708-2714. doi: 10.1093/jac/dkx205.
3
Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.不动杆菌感染的临床与病理生理学概述：一个世纪的挑战
Clin Microbiol Rev. 2017 Jan;30(1):409-447. doi: 10.1128/CMR.00058-16.
4
Multiplication of blaOXA-23 is common in clinical Acinetobacter baumannii, but does not enhance carbapenem resistance.blaOXA - 23基因在临床鲍曼不动杆菌中普遍存在，但不会增强对碳青霉烯类药物的耐药性。
J Antimicrob Chemother. 2016 Dec;71(12):3381-3385. doi: 10.1093/jac/dkw310. Epub 2016 Aug 5.
5
Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005-2014.2005 - 2014年中国细菌耐药性监测网（CHINET）报告的中国临床分离株耐药趋势。
Clin Microbiol Infect. 2016 Mar;22 Suppl 1:S9-14. doi: 10.1016/j.cmi.2016.01.001.
6
Secular trends in Acinetobacter baumannii resistance in respiratory and blood stream specimens in the United States, 2003 to 2012: A survey study.2003年至2012年美国呼吸道和血流标本中鲍曼不动杆菌耐药性的长期趋势：一项调查研究。
J Hosp Med. 2016 Jan;11(1):21-6. doi: 10.1002/jhm.2477. Epub 2015 Sep 9.
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Contribution of Acinetobacter-derived cephalosporinase-30 to sulbactam resistance in Acinetobacter baumannii.鲍曼不动杆菌中不动杆菌来源的头孢菌素酶-30对舒巴坦耐药性的作用
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Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii.鲍曼不动杆菌中舒巴坦抗菌活性及耐药决定因素的分子机制
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Structures of the class D Carbapenemases OXA-23 and OXA-146: mechanistic basis of activity against carbapenems, extended-spectrum cephalosporins, and aztreonam.类 D 碳青霉烯酶 OXA-23 和 OXA-146 的结构：对碳青霉烯类、头孢菌素类和氨曲南的作用机制基础。
Antimicrob Agents Chemother. 2013 Oct;57(10):4848-55. doi: 10.1128/AAC.00762-13. Epub 2013 Jul 22.
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TEM-1 β-lactamase as a source of resistance to sulbactam in clinical strains of Acinetobacter baumannii.TEM-1β-内酰胺酶是鲍曼不动杆菌临床菌株对舒巴坦耐药的一个来源。
J Antimicrob Chemother. 2013 Dec;68(12):2786-91. doi: 10.1093/jac/dkt275. Epub 2013 Jul 9.