• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells.厚朴酚诱导肝癌细胞凋亡并抑制ERK调节的转移潜能。
In Vivo. 2018 Nov-Dec;32(6):1361-1368. doi: 10.21873/invivo.11387.
2
Fluoxetine Induces Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits ERK/NF-κB-Modulated Anti-Apoptotic and Invasive Potential in Hepatocellular Carcinoma Cells In Vitro.氟西汀通过外在/内在途径诱导细胞凋亡，并抑制 ERK/NF-κB 调节的抗凋亡和侵袭潜能在体外肝癌细胞。
Int J Mol Sci. 2019 Feb 11;20(3):757. doi: 10.3390/ijms20030757.
3
Apoptosis induction and ERK/NF-κB inactivation are associated with magnolol-inhibited tumor progression in hepatocellular carcinoma in vivo.体内实验中，厚朴酚抑制肝癌肿瘤进展与诱导细胞凋亡及ERK/NF-κB失活有关。
Environ Toxicol. 2020 Feb;35(2):167-175. doi: 10.1002/tox.22853. Epub 2019 Nov 12.
4
Amentoflavone Inhibits ERK-modulated Tumor Progression in Hepatocellular Carcinoma .穗花杉双黄酮抑制肝细胞癌中ERK调节的肿瘤进展
In Vivo. 2018 May-Jun;32(3):549-554. doi: 10.21873/invivo.11274.
5
Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells.厚朴酚通过诱导p27KIP1介导的G2/M期细胞周期阻滞，激活人膀胱癌细胞5637中的细胞外信号调节激酶通路。
Biochem Pharmacol. 2008 Jun 15;75(12):2289-300. doi: 10.1016/j.bcp.2008.03.022. Epub 2008 Apr 8.
6
Regorafenib induces extrinsic and intrinsic apoptosis through inhibition of ERK/NF-κB activation in hepatocellular carcinoma cells.瑞戈非尼通过抑制肝癌细胞中的ERK/NF-κB激活诱导外源性和内源性凋亡。
Oncol Rep. 2017 Feb;37(2):1036-1044. doi: 10.3892/or.2016.5328. Epub 2016 Dec 20.
7
Hyperforin Inhibits Cell Growth by Inducing Intrinsic and Extrinsic Apoptotic Pathways in Hepatocellular Carcinoma Cells.金丝桃素通过诱导肝癌细胞的内源性和外源性凋亡途径抑制细胞生长。
Anticancer Res. 2017 Jan;37(1):161-167. doi: 10.21873/anticanres.11301.
8
Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice.regorafenib 通过抑制 ERK/NF-κB 激活抑制荷肝癌小鼠肿瘤进展。
Biosci Rep. 2018 May 8;38(3). doi: 10.1042/BSR20171264. Print 2018 Jun 29.
9
Glycyrrhizic Acid Modulates Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits Protein Kinase B- and Extracellular Signal-Regulated Kinase-Mediated Metastatic Potential in Hepatocellular Carcinoma and .甘草酸通过外在/内在途径调节细胞凋亡，抑制蛋白激酶 B 和细胞外信号调节激酶介导的肝癌转移潜能。
Am J Chin Med. 2020;48(1):223-244. doi: 10.1142/S0192415X20500123.
10
Suppression of PKCδ/NF-κB Signaling and Apoptosis Induction through Extrinsic/Intrinsic Pathways Are Associated Magnolol-Inhibited Tumor Progression in Colorectal Cancer In Vitro and In Vivo.姜黄素通过抑制外源性/内源性通路的 PKCδ/NF-κB 信号传导和诱导细胞凋亡抑制结直肠癌细胞的体外和体内进展。
Int J Mol Sci. 2020 May 16;21(10):3527. doi: 10.3390/ijms21103527.

引用本文的文献

1
Accessing Apoptosis Induction and Metastasis Inhibition Effect of Magnolol on Triple Negative Breast Cancer .探讨厚朴酚诱导三阴性乳腺癌细胞凋亡和抑制转移的作用。
In Vivo. 2023 May-Jun;37(3):1028-1036. doi: 10.21873/invivo.13177.
2
The Expression of Connexin 26 Regulates the Radiosensitivity of Hepatocellular Carcinoma Cells through a Mitogen-Activated Protein Kinases Signal Pathway.缝隙连接蛋白 26 的表达通过丝裂原活化蛋白激酶信号通路调节肝癌细胞的放射敏感性。
Int J Mol Sci. 2022 Nov 24;23(23):14644. doi: 10.3390/ijms232314644.
3
Magnolol as a Potential Anticancer Agent: A Proposed Mechanistic Insight.厚朴酚作为一种有潜力的抗癌药物：一种机制上的见解。
Molecules. 2022 Sep 29;27(19):6441. doi: 10.3390/molecules27196441.
4
Role of Plant-Derived Active Constituents in Cancer Treatment and Their Mechanisms of Action.植物源活性成分在癌症治疗中的作用及其作用机制。
Cells. 2022 Apr 13;11(8):1326. doi: 10.3390/cells11081326.
5
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway.虎蝎华芨软膏通过激活线粒体途径在体内外诱导肝癌细胞凋亡。
Evid Based Complement Alternat Med. 2021 Jul 15;2021:9922059. doi: 10.1155/2021/9922059. eCollection 2021.
6
Magnolol Suppresses Pancreatic Cancer Development and Negatively Regulating TGF-β/Smad Signaling.厚朴酚抑制胰腺癌发展并负向调节TGF-β/Smad信号通路。
Front Oncol. 2020 Dec 2;10:597672. doi: 10.3389/fonc.2020.597672. eCollection 2020.
7
2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression.2-O-甲基厚朴酚，一种厚朴酚衍生物，通过抑制I类组蛋白去乙酰化酶的表达来抑制肝细胞癌进展。
Front Oncol. 2020 Aug 11;10:1319. doi: 10.3389/fonc.2020.01319. eCollection 2020.
8
Extract Elevates the Cervical Cancer Cell Apoptosis Through ROS-Mitochondrial Axis Activated p38 MAPK Signaling Pathway.提取物通过 ROS-线粒体轴激活 p38 MAPK 信号通路提升宫颈癌细胞凋亡。
In Vivo. 2020 Jul-Aug;34(4):1823-1833. doi: 10.21873/invivo.11977.
9
The Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma.厚朴酚对肝癌生长的放射增敏作用。
In Vivo. 2020 Jul-Aug;34(4):1789-1796. doi: 10.21873/invivo.11973.
10
Suppression of PKCδ/NF-κB Signaling and Apoptosis Induction through Extrinsic/Intrinsic Pathways Are Associated Magnolol-Inhibited Tumor Progression in Colorectal Cancer In Vitro and In Vivo.姜黄素通过抑制外源性/内源性通路的 PKCδ/NF-κB 信号传导和诱导细胞凋亡抑制结直肠癌细胞的体外和体内进展。
Int J Mol Sci. 2020 May 16;21(10):3527. doi: 10.3390/ijms21103527.

本文引用的文献

1
Amentoflavone Inhibits ERK-modulated Tumor Progression in Hepatocellular Carcinoma .穗花杉双黄酮抑制肝细胞癌中ERK调节的肿瘤进展
In Vivo. 2018 May-Jun;32(3):549-554. doi: 10.21873/invivo.11274.
2
Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice.regorafenib 通过抑制 ERK/NF-κB 激活抑制荷肝癌小鼠肿瘤进展。
Biosci Rep. 2018 May 8;38(3). doi: 10.1042/BSR20171264. Print 2018 Jun 29.
3
Assessing the selective therapeutic efficacy of superparamagnetic erlotinib nanoparticles in lung cancer by using quantitative magnetic resonance imaging and a nuclear factor kappa-B reporter gene system.利用定量磁共振成像和核因子 κB 报告基因系统评估超顺磁载厄洛替尼纳米粒在肺癌中的选择性治疗效果。
Nanomedicine. 2018 Apr;14(3):1019-1031. doi: 10.1016/j.nano.2018.01.010. Epub 2018 Jan 31.
4
Phosphorylated ERK is a potential prognostic biomarker for Sorafenib response in hepatocellular carcinoma.磷酸化细胞外信号调节激酶是肝细胞癌中索拉非尼反应的潜在预后生物标志物。
Cancer Med. 2017 Dec;6(12):2787-2795. doi: 10.1002/cam4.1228. Epub 2017 Oct 13.
5
Amentoflavone Inhibits Metastatic Potential Through Suppression of ERK/NF-κB Activation in Osteosarcoma U2OS Cells.穗花杉双黄酮通过抑制骨肉瘤U2OS细胞中ERK/NF-κB的激活来抑制转移潜能。
Anticancer Res. 2017 Sep;37(9):4911-4918. doi: 10.21873/anticanres.11900.
6
Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway.厚朴酚通过抑制 NF-κB 信号通路抑制胆管癌细胞的增殖和侵袭。
Biomed Pharmacother. 2017 Oct;94:474-480. doi: 10.1016/j.biopha.2017.07.085. Epub 2017 Aug 3.
7
Regorafenib diminishes the expression and secretion of angiogenesis and metastasis associated proteins and inhibits cell invasion via NF-κB inactivation in SK-Hep1 cells.瑞戈非尼可降低血管生成和转移相关蛋白的表达与分泌，并通过使SK-Hep1细胞中的核因子κB失活来抑制细胞侵袭。
Oncol Lett. 2017 Jul;14(1):461-467. doi: 10.3892/ol.2017.6142. Epub 2017 May 9.
8
Add-On Therapy with Traditional Chinese Medicine Improves Outcomes and Reduces Adverse Events in Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials.中药辅助治疗改善肝细胞癌的预后并减少不良事件：一项随机对照试验的荟萃分析
Evid Based Complement Alternat Med. 2017;2017:3428253. doi: 10.1155/2017/3428253. Epub 2017 Jun 7.
9
Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents.中药厚朴及其成分的生物活性与毒性
J Zhejiang Univ Sci B. 2017;18(3):194-214. doi: 10.1631/jzus.B1600299.
10
Hyperforin Inhibits Cell Growth by Inducing Intrinsic and Extrinsic Apoptotic Pathways in Hepatocellular Carcinoma Cells.金丝桃素通过诱导肝癌细胞的内源性和外源性凋亡途径抑制细胞生长。
Anticancer Res. 2017 Jan;37(1):161-167. doi: 10.21873/anticanres.11301.

厚朴酚诱导肝癌细胞凋亡并抑制ERK调节的转移潜能。

Magnolol Induces Apoptosis and Inhibits ERK-modulated Metastatic Potential in Hepatocellular Carcinoma Cells.

作者信息

Kuan Lin-Yen, Chen Wei-Lung, Chen Jiann-Hwa, Hsu Fei-Ting, Liu Tsu-Te, Chen Wei-Ting, Wang Kai-Lee, Chen Wen-Chang, Liu Yu-Chang, Wang Wei-Shu

机构信息

Department of Emergency Medicine, Cathay General Hospital, Taipei, Taiwan, R.O.C.

School of Medicine, Fu Jen Catholic University, Taipei, Taiwan, R.O.C.

出版信息

In Vivo. 2018 Nov-Dec;32(6):1361-1368. doi: 10.21873/invivo.11387.

DOI:10.21873/invivo.11387
PMID:30348689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6365719/
Abstract

BACKGROUND/AIM: The aim of the present study was to evaluate the anti-cancer effect of magnolol in hepatocellular carcinoma (HCC) cells in vitro.

MATERIALS AND METHODS

HCC SK-Hep1 cells were treated with different concentrations of magnolol or PD98059 [extracellular-signal-regulated kinase (ERK) inhibitor] for 48 h, and then cell viability, apoptosis, signal transduction, expression of anti-apoptotic and metastasis-related proteins, and cell invasion were investigated by [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay, flow cytometry, nuclear factor kappa B (NF-ĸB) reporter gene, western blotting, and cell invasion assays.

RESULTS

Magnolol significantly induced accumulation of sub-G phase and caspase-3 activation and inhibited NF-ĸB activation, cell invasion, expression of phosphorylated ERK (pERK), anti-apoptotic and metastatic-related proteins. ERK inactivation was required for magnolol-induced inhibition of metastatic potential of SK-Hep1 cells.

CONCLUSION

Taken together, these results indicated that magnolol not only induced apoptosis, but also inhibited ERK-modulated metastatic potential of HCC SK-Hep1 cells.

摘要

背景/目的：本研究旨在评估厚朴酚对体外培养的肝癌（HCC）细胞的抗癌作用。

材料与方法

用不同浓度的厚朴酚或PD98059[细胞外信号调节激酶（ERK）抑制剂]处理肝癌SK-Hep1细胞48小时，然后通过[3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐]（MTT）法、流式细胞术、核因子κB（NF-κB）报告基因、蛋白质印迹法和细胞侵袭实验，研究细胞活力、凋亡、信号转导、抗凋亡和转移相关蛋白的表达以及细胞侵袭情况。

结果

厚朴酚显著诱导亚G期细胞堆积和半胱天冬酶-3激活，并抑制NF-κB激活、细胞侵袭、磷酸化ERK（pERK）、抗凋亡和转移相关蛋白的表达。厚朴酚诱导SK-Hep1细胞转移潜能抑制需要ERK失活。

结论

综上所述，这些结果表明厚朴酚不仅诱导凋亡，还抑制肝癌SK-Hep1细胞中ERK调节的转移潜能。