Walter Joan, Bojanic Bojan, Dittli Manuel, Fehr Nadia, Sartoretti Thomas, Schwyzer Moritz, Binz Katharina, Gennari Antonio G, Ernst Matthias, Huellner Martin W, Messerli Michael
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.
Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
J Clin Transl Endocrinol. 2025 Jun 26;41:100405. doi: 10.1016/j.jcte.2025.100405. eCollection 2025 Sep.
To assess the glycemic status of consecutive melanoma patients undergoing standardized capillary fasting blood glucose (cFBG) assessment prior to fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) examination.
This retrospective study included 336 consecutive melanoma patients at the University Hospital Zurich, Switzerland. Fasting cFBG levels were measured prior to FDG PET/CT and classified according to American Diabetes Association guidelines. Multivariable linear regression analysis was performed to identify independent predictors of cFBG levels. Sensitivity analyses were performed on patients examined before 11 AM and fasting for 8 h as well as patients without known diabetes.
The cohort included 336 melanoma patients with a median age of 67 years (IQR 57-76), 36 % female (122/336), and 12 % (40/336) with known diabetes mellitus. The median cFBG was 103 mg/dL (IQR 94-112; 5.7 mmol/L, IQR 5.2-6.2). Overall, 58 % (194/336) of patients had non-normal cFBG levels (≥100 mg/dL; ≥5.6 mmol/L), consistent with findings from a sensitivity analysis of patients presenting before 11 AM, where 58 % (115/198) exhibited non-normal levels. Excluding patients with known diabetes, 56 % (165/296) of patients had non-normal cFBG levels, with 7 % (20/210) having levels ≥126 mg/dL (≥7.0 mmol/L), indicative of possible undiagnosed diabetes mellitus. Multivariable linear regression analysis identified male gender, active disease, and subcutaneous fat as independent predictors of cFBG levels, whereas traditional risk factors such as BMI, visceral fat, hypertension or lack of exercise were not independent predictors.
More than half of melanoma patients have elevated cFBG levels, even in those without known diabetes, highlighting the need for improved glycemic screening and management.
评估在接受氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（FDG PET/CT）检查之前进行标准化毛细血管空腹血糖（cFBG）评估的连续性黑色素瘤患者的血糖状态。
这项回顾性研究纳入了瑞士苏黎世大学医院的336例连续性黑色素瘤患者。在FDG PET/CT检查之前测量空腹cFBG水平，并根据美国糖尿病协会指南进行分类。进行多变量线性回归分析以确定cFBG水平的独立预测因素。对上午11点之前检查且禁食8小时的患者以及无已知糖尿病的患者进行敏感性分析。
该队列包括336例黑色素瘤患者，中位年龄为67岁（四分位间距57 - 76岁），36%为女性（122/336），12%（40/336）患有已知糖尿病。中位cFBG为103mg/dL（四分位间距94 - 112；5.7mmol/L，四分位间距5.2 - 6.2）。总体而言，58%（194/336）的患者cFBG水平不正常（≥100mg/dL；≥5.6mmol/L），这与上午11点之前就诊患者的敏感性分析结果一致，其中58%（115/198）表现出不正常水平。排除已知糖尿病患者后，56%（165/296）的患者cFBG水平不正常，7%（20/210）的患者水平≥126mg/dL（≥7.0mmol/L），提示可能存在未诊断的糖尿病。多变量线性回归分析确定男性、疾病活动和皮下脂肪是cFBG水平的独立预测因素，而传统风险因素如BMI、内脏脂肪、高血压或缺乏运动不是独立预测因素。
超过一半的黑色素瘤患者cFBG水平升高，即使在无已知糖尿病的患者中也是如此，这突出了改善血糖筛查和管理的必要性。
