Hinojosa R, Lindsay J R
Arch Otolaryngol. 1977 Nov;103(11):634-40. doi: 10.1001/archotol.1977.00780280034003.
A 9-year-old girl developed Reye's syndrome. On admission to the hospital on the fourth day of illness, responses for verbal stimuli had been absent, but were present for painful stimuli. Coma developed on the fourth day and was present until death ten days later. The fundus of both internal meatus showed vascular congestion of nerves with evidence of repeated hemorrhages. All structures within the endolymphatic system showed advanced degeneration, with exception of the tectorial membrane and cupulae. One ear showed vascular congestion, formation of thrombi, and free hemorrhage within the modiolus and spiral ganglion. In the other ear, congested vessels in nerves in the meatus were obstructed by swelling at the cribriform area. The degenerative changes corresponded closely to those produced experimentally in guinea pigs by interruption of arterial circulation to the inner ear.
一名9岁女孩患上了瑞氏综合征。在患病第四天入院时，对言语刺激无反应，但对疼痛刺激有反应。第四天出现昏迷，一直持续到十天后死亡。双侧内耳道眼底显示神经血管充血，有反复出血迹象。内淋巴系统内所有结构均显示出晚期变性，除了盖膜和壶腹嵴。一只耳朵显示血管充血、血栓形成，以及蜗轴和螺旋神经节内有游离出血。另一只耳朵，内耳道神经中的充血血管在筛状区因肿胀而阻塞。这些退行性变化与通过中断内耳动脉循环在豚鼠身上实验性产生的变化非常相似。
