儿童全基因组 DNA 甲基化中早期生活社会经济地位和家庭逆境的生物学嵌入。
The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.
机构信息
Department of Psychiatry, Center for Health & Community, Weill Neuroscience Institute, University of California, San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118, USA.
Department of Pediatrics, Division of Developmental Medicine, University of California, San Francisco, 550 16th Street, San Francisco, CA 94158, USA.
出版信息
Epigenomics. 2018 Nov;10(11):1445-1461. doi: 10.2217/epi-2018-0042. Epub 2018 Oct 23.
AIM
To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course.
MATERIALS & METHODS: In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined.
RESULTS
Family income, parental education and family psychosocial adversity each associated with increased or decreased DNA methylation (488, 354 and 102 sites, respectively) within a unique set of genomic CpG sites. Gene ontology analyses pointed to genes serving immune and developmental regulation functions.
CONCLUSION
Findings provided support for DNA methylation as a biomarker linking early-life social experiences with later life health in humans.
目的
研究儿童 DNA 甲基化的变化，评估其作为儿童期社会逆境对整个生命过程中健康影响的途径的潜力。
材料与方法
在一个多样化的、前瞻性的社区样本中，对 178 名幼儿园儿童进行了三种社会经历与儿童期后期口腔上皮细胞内 DNA 甲基化之间的相关性研究。
结果
家庭收入、父母教育水平和家庭心理社会逆境分别与一组独特的基因组 CpG 位点内的 DNA 甲基化增加或减少（分别为 488、354 和 102 个位点）相关。基因本体分析表明，这些基因具有免疫和发育调节功能。
结论
这些发现为 DNA 甲基化作为一种生物标志物提供了支持，该标志物将人类生命早期的社会经历与生命后期的健康联系起来。
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