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饮食中非酶抗氧化能力与心肌梗死风险：瑞典全国三月队列研究。

Dietary non-enzymatic antioxidant capacity and the risk of myocardial infarction: the Swedish National March Cohort.

机构信息

Department of Statistics and Quantitative Methods, University of Milano Bicocca, Milan, Italy.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

出版信息

Int J Epidemiol. 2018 Dec 1;47(6):1947-1955. doi: 10.1093/ije/dyy220.

DOI:10.1093/ije/dyy220

PMID:30351384

Abstract

BACKGROUND

Results from randomized trials of antioxidant supplementation have cast doubt on observational data linking diets high in antioxidants to a reduced risk of cardiovascular diseases. We hypothesized that supplementation of one or a few antioxidants might not simulate the complex actions of all antioxidants in the human diet. We therefore investigated the association between dietary Non Enzymatic Antioxidant Capacity (NEAC), reflecting the antioxidant potential of the whole diet, and the risk of myocardial infarction (MI).

METHODS

In the Swedish National March Cohort, 34 543 men and women free from cardiovascular diseases and cancer were followed through record linkages from 1997 until 2010. NEAC was assessed with a validated food-frequency questionnaire at baseline. The distribution of NEAC was categorized into sex-specific quartiles. We fitted multivariable Cox proportional hazards regression models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs).

RESULTS

During a mean follow-up time of 12.7 years, we identified 1142 incident cases of MI. Successively higher quartiles (Qs) of dietary NEAC were accompanied by a monotonic trend of decreasing MI incidence, both for overall MI (HR Q4 vs Q1: 0.77; 95% CI: 0.61-0.96; p for trend = 0.008) and non-fatal MI (HR Q4 vs Q1: 0.72; 95% CI: 0.56-0.92; p for trend = 0.004). No such association was found for fatal MI.

CONCLUSIONS

A diet rich in antioxidants might protect from MI.

摘要

背景

抗氧化剂补充剂的随机试验结果使人们对将富含抗氧化剂的饮食与降低心血管疾病风险联系起来的观察数据产生了怀疑。我们假设，补充一种或几种抗氧化剂可能无法模拟人类饮食中所有抗氧化剂的复杂作用。因此，我们研究了饮食中非酶抗氧化能力（NEAC）与心肌梗死（MI）风险之间的关系，该能力反映了整个饮食的抗氧化潜力。

方法

在瑞典国家 3 月队列中，34543 名无心血管疾病和癌症的男性和女性从 1997 年开始通过记录链接进行随访，直至 2010 年。在基线时使用经过验证的食物频率问卷评估 NEAC。根据性别将 NEAC 的分布分为四分位数。我们使用多变量 Cox 比例风险回归模型来估计危险比（HR）及其 95%置信区间（CI）。

结果

在平均 12.7 年的随访期间，我们确定了 1142 例 MI 事件。随着饮食 NEAC 的四分位（Qs）逐渐升高，MI 发生率呈单调下降趋势，总 MI（HR Q4 与 Q1：0.77；95%CI：0.61-0.96；p 趋势=0.008）和非致命性 MI（HR Q4 与 Q1：0.72；95%CI：0.56-0.92；p 趋势=0.004）均如此。对于致命性 MI，未发现这种关联。