Suppr
超能文献

饮食抗氧化剂与帕金森病风险：瑞典全国三月队列研究。

Dietary Antioxidants and the Risk of Parkinson Disease: The Swedish National March Cohort.

机构信息

From the Department of Statistics and Quantitative Methods (E.H., R.B.), University of Milano-Bicocca, Milan; Institute for Biomedicine, Eurac Research (E.H.), Affiliated Institute of the University of Lübeck, Bolzano, Italy; Clinical Epidemiology Division, Department of Medicine (Solna) (Y.T.L., S.B.), and Department of Medical Epidemiology and Biostatistics (W.Y., H.-O.A., R.B.), Karolinska Institutet, Stockholm; Obesity Center, Academic Specialist Center (Y.T.L.), Stockholm Health Services, Sweden; Functional Food and Metabolic Stress Prevention Laboratory, Faculty of BioSciences and Technology for Food, Agriculture and Environment (M.S.), University of Teramo, Italy; and Clinical Effectiveness Research Group, Institute of Health (H.-O.A.), University of Oslo, Norway.

出版信息

Neurology. 2021 Feb 9;96(6):e895-e903. doi: 10.1212/WNL.0000000000011373. Epub 2021 Jan 6.

DOI:10.1212/WNL.0000000000011373

PMID:33408141

Abstract

OBJECTIVE

To determine whether high baseline dietary antioxidants and total nonenzymatic antioxidant capacity (NEAC) is associated with a lower risk of Parkinson disease (PD) in men and women, we prospectively studied 43,865 men and women from a large Swedish cohort.

METHODS

In the Swedish National March Cohort, 43,865 men and women aged 18-94 years were followed through record linkages to National Health Registries from 1997 until 2016. Baseline dietary vitamin E, vitamin C, and beta-carotene intake, as well as NEAC, were assessed by a validated food frequency questionnaire collected at baseline. All exposure variables were adjusted for energy intake and categorized into tertiles. Multivariable Cox proportional hazard regression models were fitted to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for PD.

RESULTS

After a mean follow-up time of 17.6 years, we detected 465 incidence cases of PD. In the multivariable adjusted model, dietary vitamin E (HR 0.68, 95% CI 0.52-0.90; for trend 0.005) and vitamin C (HR 0.68, 95% CI 0.52-0.89; for trend 0.004) were inversely associated with the risk of PD when comparing participants in the highest vs the lowest tertiles of exposure. No association was found with estimated intake of dietary beta-carotene or NEAC.

CONCLUSION

Our findings suggest that dietary vitamin E and C intake might be inversely associated with the risk of PD. No association was found with dietary beta-carotene or NEAC.

CLASSIFICATION OF EVIDENCE

This study provides Class III evidence that dietary vitamin E and C intake are inversely associated with the risk of PD.

摘要

目的

为了确定基线饮食中抗氧化剂和总非酶抗氧化能力（NEAC）较高是否与男性和女性帕金森病（PD）风险降低相关，我们前瞻性地研究了来自大型瑞典队列的 43865 名男性和女性。

方法

在瑞典国家 3 月队列中，对 43865 名年龄在 18-94 岁的男性和女性进行了随访，通过记录链接到国家健康登记册，从 1997 年持续到 2016 年。基线时通过验证的食物频率问卷评估了饮食中维生素 E、维生素 C 和β-胡萝卜素的摄入量以及 NEAC。所有暴露变量均根据能量摄入进行调整，并分为三分位。使用多变量 Cox 比例风险回归模型来估计 PD 的风险比（HR）及其 95%置信区间（CI）。

结果

在平均 17.6 年的随访期间，我们检测到 465 例 PD 发病病例。在多变量调整模型中，与最低三分位组相比，饮食中维生素 E（HR 0.68，95%CI 0.52-0.90；趋势检验 P=0.005）和维生素 C（HR 0.68，95%CI 0.52-0.89；趋势检验 P=0.004）与 PD 风险呈负相关。饮食β-胡萝卜素或 NEAC 摄入量与 PD 风险无关联。