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在人类I型嗜T细胞病毒长末端重复序列中鉴定p40x反应性调控序列。

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat.

作者信息

Brady J, Jeang K T, Duvall J, Khoury G

出版信息

J Virol. 1987 Jul;61(7):2175-81. doi: 10.1128/JVI.61.7.2175-2181.1987.

DOI:10.1128/JVI.61.7.2175-2181.1987
PMID:3035218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC254240/
Abstract

Distinct transcriptional regulatory sequences located within the upstream sequences required for p40x trans-activation of the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR) were chemically synthesized and cloned upstream of the basal HTLV-I LTR promoter. Plasmids containing a single 21-base-pair (bp) repeat were weakly inducible by p40x. The level of trans-activation by p40x was increased when two (30-fold) or three (40-fold) 21-bp repeats were present in the upstream control region. In the mutant containing two 21-bp repeats, the upstream 21-bp repeat could be positioned in either the sense (30-fold) or the antisense (16-fold) orientation. Plasmids containing a 51-bp repeat element, which included a single 21-bp repeat, were induced to levels similar to that obtained with the 21-bp repeat sequence alone. Template DNAs containing a single copy of the HTLV-I sequences between -117 and -160 were stimulated approximately 10-fold by p40x when one copy of the 21-bp element was located downstream.

摘要

位于人类I型嗜T细胞病毒（HTLV-I）长末端重复序列（LTR）的p40x反式激活所需上游序列内的不同转录调控序列被化学合成，并克隆到基础HTLV-I LTR启动子的上游。含有单个21碱基对（bp）重复序列的质粒对p40x的诱导作用较弱。当上游控制区存在两个（30倍）或三个（40倍）21-bp重复序列时，p40x的反式激活水平会升高。在含有两个21-bp重复序列的突变体中，上游21-bp重复序列可以以正义（30倍）或反义（16倍）方向定位。含有一个51-bp重复元件（其中包括一个单一的21-bp重复序列）的质粒被诱导到与单独使用21-bp重复序列时相似的水平。当一个21-bp元件的拷贝位于下游时，含有-117至-160之间HTLV-I序列单拷贝的模板DNA被p40x刺激约10倍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/188a/254240/495a4b284497/jvirol00098-0127-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/188a/254240/cc5426cafadf/jvirol00098-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/188a/254240/198a92c495f2/jvirol00098-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/188a/254240/495a4b284497/jvirol00098-0127-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/188a/254240/cc5426cafadf/jvirol00098-0125-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/188a/254240/198a92c495f2/jvirol00098-0126-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/188a/254240/495a4b284497/jvirol00098-0127-a.jpg

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