Bullard Whitney L, Flemington Erik K, Renne Rolf, Tibbetts Scott A
Department of Molecular Genetics and Microbiology, UF Health Cancer Center, University of Florida, Gainesville, FL, USA.
Department of Pathology, Tulane Cancer Center, Tulane University, New Orleans, LA, USA.
Trends Cancer. 2018 Nov;4(11):729-740. doi: 10.1016/j.trecan.2018.09.005. Epub 2018 Oct 10.
EBV and KSHV are etiologic agents of multiple types of lymphomas and carcinomas. The frequency of EBV or KSHV malignancies arising in immunocompromised individuals reflects the intricate evolutionary balance established between these viruses and their immunocompetent hosts. However, the specific mechanisms by which these pathogens drive tumorigenesis remain poorly understood. In recent years an enormous array of cellular and viral noncoding RNAs (ncRNAs) have been discovered, and host ncRNAs have been revealed as contributory factors to every single cancer hallmark cellular process. As new evidence emerges that gammaherpesvirus ncRNAs also alter host processes and viral factors dysregulate host ncRNA expression, and as novel viral ncRNAs continue to be discovered, we examine the contribution of small, non-miRNA ncRNAs and long ncRNAs to gammaherpesvirus tumorigenesis.
EBV和KSHV是多种淋巴瘤和癌的病原体。免疫功能低下个体中出现EBV或KSHV恶性肿瘤的频率反映了这些病毒与其免疫功能正常宿主之间建立的复杂进化平衡。然而，这些病原体驱动肿瘤发生的具体机制仍知之甚少。近年来，已发现大量细胞和病毒非编码RNA（ncRNA），并且宿主ncRNA已被揭示为每个癌症标志性细胞过程的促成因素。随着新证据表明γ疱疹病毒ncRNA也会改变宿主过程且病毒因子会失调宿主ncRNA表达，以及随着新型病毒ncRNA不断被发现，我们研究了小型非miRNA ncRNA和长链ncRNA对γ疱疹病毒肿瘤发生的作用。
