Bhatt P N, Jacoby R O
Lab Anim Sci. 1987 Feb;37(1):11-5.
Clinical responses to infection with ectromelia virus strain NIH-79 were determined in several strains of inbred mice. All mice were equally susceptible to infection, but mortality was strain dependent. BALB/c AnNCr, A/JNCr, DBA/2NCr and C3H/He/NCr MTV- mice were highly susceptible to lethal infection whereas AKR/NCr and SJL/NCr mice were moderately susceptible and C57BL/6NCr mice were highly resistant. Death rates were influenced strongly by virus dose and by route of inoculation. High doses were associated with early and high mortality. For a given dose, intraperitoneal inoculation resulted in the highest mortality and death rates were progressively reduced in mice inoculated by the footpad, subcutaneous and intranasal routes. Footpad swelling was prominent in resistant mice and in survivors among susceptible strains. Deaths among AKR and SJL mice were sporadic and often occurred late irrespective of virus dose. It is suggested that this pattern could be influenced by secondary contact infections or by immunologic injury associated with host responses to ectromelia virus.
在多个近交系小鼠品系中测定了对埃可病毒NIH - 79株感染的临床反应。所有小鼠对感染的易感性相同，但死亡率因品系而异。BALB/c AnNCr、A/JNCr、DBA/2NCr和C3H/He/NCr MTV -小鼠对致死性感染高度易感，而AKR/NCr和SJL/NCr小鼠中度易感，C57BL/6NCr小鼠高度抗性。死亡率受病毒剂量和接种途径的强烈影响。高剂量与早期和高死亡率相关。对于给定剂量，腹腔接种导致最高死亡率，而通过足垫、皮下和鼻内途径接种的小鼠死亡率逐渐降低。足垫肿胀在抗性小鼠和易感品系的存活者中很明显。AKR和SJL小鼠的死亡是散发性的，且无论病毒剂量如何，通常发生在后期。有人认为，这种模式可能受二次接触感染或与宿主对埃可病毒反应相关的免疫损伤影响。
