Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.
Cardiology Group, Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain.
J Cardiovasc Transl Res. 2019 Jun;12(3):231-239. doi: 10.1007/s12265-018-9840-y. Epub 2018 Oct 23.
A obesity paradox has been described following heart failure (HF). The aim of this study was to analyze the association between food intake-involved adipokines and long-term weight changes. Leptin, adiponectin, and omentin were analyzed in 92 acute HF (AHF) patients at discharge, classified on the basis of weight gains or losses > 6%. The mean follow-up was 256 ± 143 days. Leptin and adiponectin levels were similar among weight groups. However, omentin levels were higher in those patients who had gained weight (16 ± 5 ng/mL) than in those who had lost weight (12 ± 4 ng/mL) or showed no weight change (11 ± 5 ng/mL; p < 0.002). Omentin levels were the best independent predictors for patients with weight gain, who had less mortality and hospital readmission during the follow-up. The association between omentin levels and weight gain might explain part of the obesity paradox in HF.
肥胖悖论在心力衰竭（HF）后被描述。本研究旨在分析与饮食摄入相关的脂肪因子与长期体重变化之间的关系。在出院时，对 92 例急性心力衰竭（AHF）患者进行了瘦素、脂联素和网膜素的分析，根据体重增加或减少>6%进行分类。平均随访时间为 256±143 天。体重组之间的瘦素和脂联素水平相似。然而，与体重减轻（12±4ng/ml）或体重无变化（11±5ng/ml）的患者相比，体重增加（16±5ng/ml）的患者网膜素水平更高（p<0.002）。在随访期间，网膜素水平是体重增加患者的最佳独立预测因子，其死亡率和再入院率较低。网膜素水平与体重增加之间的关联可能部分解释了 HF 中的肥胖悖论。
