Huang Ying, Lin Yingzhong, Zhang Shumin, Wang Zhijian, Zhang Jianwei, Chang Chao, Liu Ling, Ji Qingwei, Liu Xiaofei
Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
Department of Cardiology, The People's Hospital of Juxian, Juxian 276500, China.
Dis Markers. 2016;2016:6762825. doi: 10.1155/2016/6762825. Epub 2016 May 24.
Background. Recent evidence demonstrated that the circulating levels of omentin-1 are related to the presence of ischemic heart disease and heart failure. However, omentin-1 plasma levels in patients with nonischemic dilated cardiomyopathy (DCM), which is the most common etiology of heart failure, have yet to be investigated. Methods. Plasma levels of omentin-1 and adiponectin were measured in 100 patients with DCM and 45 healthy controls. Results. Plasma omentin-1 levels significantly decreased in DCM patients compared with the control group, whereas adiponectin levels significantly increased in DCM patients compared with the control group. Plasma omentin-1 levels were negatively correlated with adiponectin (R = -0.376, P = 0.005), C-reactive protein (CRP) (R = -0.320, P = 0.001), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (R = -0.365, P = 0.000) levels as well as left ventricular end-diastolic diameter (LVEDD) (R = -0.200, P = 0.046) but were positively correlated with left ventricular ejection fraction (LVEF) (R = 0.496, P = 0.000). Plasma adiponectin levels were positively correlated with CRP (R = 0.273, P = 0.006) and NT-proBNP (R = 0.329, P = 0.001) levels but were negatively correlated with fasting glucose (R = -0.218, P = 0.029) and LVEF (R = -0.615, P = 0.000) levels. Furthermore, omentin-1 (OR 0.983, 95% CI 0.970 to 0.996; P = 0.008) levels were independently associated with the presence of DCM before NT-proBNP was added. Conclusions. Omentin-1 is a novel biomarker of DCM.
背景。近期证据表明，网膜素-1的循环水平与缺血性心脏病和心力衰竭的存在有关。然而，非缺血性扩张型心肌病（DCM）是心力衰竭最常见的病因，其患者的网膜素-1血浆水平尚未得到研究。方法。测定了100例DCM患者和45名健康对照者的血浆网膜素-1和脂联素水平。结果。与对照组相比，DCM患者的血浆网膜素-1水平显著降低，而与对照组相比，DCM患者的脂联素水平显著升高。血浆网膜素-1水平与脂联素（R = -0.376，P = 0.005）、C反应蛋白（CRP）（R = -0.320，P = 0.001）、N末端脑钠肽前体（NT-proBNP）（R = -0.365，P = 0.000）水平以及左心室舒张末期内径（LVEDD）（R = -0.200，P = 0.046）呈负相关，但与左心室射血分数（LVEF）（R = 0.496，P = 0.000）呈正相关。血浆脂联素水平与CRP（R = 0.273，P = 0.006）和NT-proBNP（R = 0.329，P = 0.001）水平呈正相关，但与空腹血糖（R = -0.218，P = 0.029）和LVEF（R = -0.615，P = 0.000）水平呈负相关。此外，在加入NT-proBNP之前，网膜素-1水平（OR 0.983，95%CI 0.970至0.996；P = 0.008）与DCM的存在独立相关。结论。网膜素-1是DCM的一种新型生物标志物。
