Ostrovskaya R U, Ivanov S V, Durnev A D
Laboratory of Psychopharmacology, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Bull Exp Biol Med. 2018 Oct;165(6):758-762. doi: 10.1007/s10517-018-4259-7. Epub 2018 Oct 23.
We studied antidiabetic effects and cytoprotective activity of two lithium salts (lithium chloride and lithium carbonate) on the model of streptozotocin-induced diabetes mellitus type 2 in Wistar rats. Using the method of β-cells detection with antibodies to insulin, we demonstrated that streptozotocin reduced the number of β-cells and impaired their morphological structure. Both lithium preparations administered to diabetic animals for 28 days in doses of 10 and 8.9 mg/kg, respectively, attenuated the damaging effect of streptozotocin. This cytoprotective effect of lithium salts manifested in weakening of hyperglycemia, polyphagia, polydipsia, and weight loss. A satisfactory correlation between the morphometric data and blood glucose levels was revealed. The mechanisms of the multitarget action of lithium salts are discussed.
我们研究了两种锂盐（氯化锂和碳酸锂）对链脲佐菌素诱导的Wistar大鼠2型糖尿病模型的抗糖尿病作用和细胞保护活性。使用抗胰岛素抗体检测β细胞的方法，我们证明链脲佐菌素减少了β细胞的数量并损害了它们的形态结构。分别以10和8.9 mg/kg的剂量给糖尿病动物施用两种锂制剂28天，均减弱了链脲佐菌素的损伤作用。锂盐的这种细胞保护作用表现为高血糖、多食、多饮和体重减轻的减弱。形态学数据与血糖水平之间存在良好的相关性。讨论了锂盐多靶点作用的机制。
