Brunell P A, Geiser C F, Novelli V, Lipton S, Narkewicz S
Pediatrics. 1987 Jun;79(6):922-7.
A varicella-like illness occurred in five of 52 children with acute lymphocytic leukemia following the administration of live varicella vaccine. Only one of the children required treatment with acyclovir. Virus isolated from two of the children was "vaccine-like" but differed slightly from the original vaccine strain when tested by restriction enzyme analysis. There did not appear to be a reversion to virulence because two of the household contacts who seroconverted had mild or subclinical infections. Vaccinees in whom this reaction developed tended to have a poor cellular immune response to varicella-zoster virus.
在52名急性淋巴细胞白血病儿童接种水痘活疫苗后，有5名儿童出现了类似水痘的疾病。其中只有一名儿童需要用阿昔洛韦进行治疗。从两名儿童身上分离出的病毒为“疫苗样”病毒，但经限制性酶切分析检测，其与原始疫苗株略有不同。由于两名血清转化的家庭接触者出现了轻度或亚临床感染，因此似乎不存在毒力回复现象。出现这种反应的接种者对水痘-带状疱疹病毒的细胞免疫反应往往较差。
