Brunell P A, Taylor-Wiedeman J, Geiser C F, Frierson L, Lydick E
Pediatrics. 1986 Jan;77(1):53-6.
A study was undertaken to determine whether children immunized with live varicella vaccine are at greater risk of acquiring herpes zoster than children who have had varicella. Children with acute lymphocytic leukemia who had had varicella were compared with those who received live varicella vaccine. During the period of observation, 15 of 73 children who had varicella acquired herpes zoster and none of the 34 children who had been vaccinated. If the time of observation was adjusted for and the vaccinees who failed to have a sustained antibody response or who acquired chickenpox were removed, the risk of herpes zoster was still less in vaccinees (P = .0075). Because herpes zoster is common in children with acute lymphocytic leukemia, differences in the two groups could be discerned more readily than if normal children were compared. There is no reason to suspect that recipients of live varicella vaccine would be more likely to acquire herpes zoster than children who get varicella.
开展了一项研究，以确定接种水痘减毒活疫苗的儿童比患过水痘的儿童发生带状疱疹的风险是否更高。将患过水痘的急性淋巴细胞白血病患儿与接种水痘减毒活疫苗的患儿进行比较。在观察期间，73名患过水痘的儿童中有15名发生了带状疱疹，而34名接种疫苗的儿童中无人发生。如果对观察时间进行校正，并排除未产生持续抗体反应或患过水痘的疫苗接种者，疫苗接种者发生带状疱疹的风险仍然较低（P = 0.0075）。由于带状疱疹在急性淋巴细胞白血病患儿中很常见，因此与比较正常儿童相比，两组之间的差异更容易辨别。没有理由怀疑接种水痘减毒活疫苗的儿童比患水痘的儿童更易发生带状疱疹。
