时间与衰老的度量。
Time and the Metrics of Aging.
机构信息
From the Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD (L.F., P.-L.K., E.M.S.).
Department of Pathology, Yale School of Medicine, New Haven, CT (M.E.L.).
出版信息
Circ Res. 2018 Sep 14;123(7):740-744. doi: 10.1161/CIRCRESAHA.118.312816.
The study of aging relates to changes in physical and functional dimensions that occur over time in living organisms. Yet, a model that establishes the and of molecular, phenotypic, and functional hierarchical domains of aging in humans has not been established. We propose that studying the mechanisms and consequences of aging through the lens of these hierarchical domains and their connections will provide clarity in semantics and enhance a translational perspective. The study of human aging would be most informative from a life course, longitudinal perspective, given that manifestations of aging are already detectable early in life at the molecular level, yet the phenotypic responses remain masked by compensatory/resiliency mechanisms. Understanding the nature of these mechanisms is paramount for developing interventions that reduce the burden of disease and disability in older persons.
衰老研究涉及生物体内随时间发生的身体和功能维度的变化。然而，尚未建立一个能够确定人类分子、表型和功能层次领域衰老的和的模型。我们提出，通过这些层次领域及其联系的视角来研究衰老的机制和后果，将在语义上提供清晰性，并增强转化视角。鉴于衰老的表现早在生命早期的分子水平上就已经可以检测到，而表型反应仍然被代偿/弹性机制所掩盖，因此从生命过程的纵向角度来看，对人类衰老的研究将是最有意义的。了解这些机制的性质对于开发干预措施至关重要，这些干预措施可以减轻老年人的疾病和残疾负担。
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