From the Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Spain.
Circ Res. 2018 Sep 14;123(7):905-924. doi: 10.1161/CIRCRESAHA.118.312204.
Model organisms have provided fundamental evidence that aging can be delayed and longevity extended. These findings gave rise to a new era in aging research aimed at elucidating the pathways and networks controlling this complex biological process. The identification of 9 hallmarks of aging has established a framework to evaluate the relative contribution of each hallmark and the interconnections among them. In this review, we revisit these hallmarks with the information obtained exclusively through the generation of genetically modified mouse models that have a significant impact on the aging process. We discuss within each hallmark those interventions that accelerate aging or that have been successful at increasing lifespan, with the final goal of identifying the most promising antiaging avenues based on the current knowledge provided by in vivo models.
模式生物为衰老可以延缓和寿命延长提供了基本证据。这些发现开创了衰老研究的新纪元，旨在阐明控制这一复杂生物学过程的途径和网络。9 大衰老标志的确定为评估每个标志的相对贡献及其相互关系建立了一个框架。在这篇综述中，我们利用仅通过基因修饰小鼠模型获得的信息重新审视这些标志，这些模型对衰老过程有重大影响。我们在每个标志内讨论那些加速衰老或成功延长寿命的干预措施，最终目标是根据体内模型提供的现有知识，确定最有前途的抗衰老途径。
