巴西人类源非克隆mcr-1阳性大肠杆菌中多粘菌素耐药水平较低。
Low level of polymyxin resistance among nonclonal mcr-1-positive Escherichia coli from human sources in Brazil.
作者信息
Pillonetto Marcelo, Mazzetti Alana, Becker Guilherme N, Siebra Christian A, Arend Lavinia N V S, Barth Afonso L
机构信息
State Public Health Laboratory of Paraná, São José dos Pinhais, Brazil; Pontifical Catholic University of Paraná, Curitiba, Brazil; Instituto Nacional de Pesquisa em Resistência Antimicrobiana-INPRA, Brazil.
Pontifical Catholic University of Paraná, Curitiba, Brazil.
出版信息
Diagn Microbiol Infect Dis. 2019 Feb;93(2):140-142. doi: 10.1016/j.diagmicrobio.2018.08.009. Epub 2018 Aug 26.
We report 26 human isolates of mcr-1-positive Escherichia coli, most of them (65.4%) with a polymyxin B MIC of 2 mg/L. Seventeen out of the 24 mcr-1-positive E. coli proved to be nonclonal by rep-PCR which strengthens the hypothesis of environmental or animal origin of these strains and reinforces the one health context of antimicrobial resistance.
我们报告了26株mcr-1阳性大肠杆菌的人类分离株，其中大多数（65.4%）对多粘菌素B的最低抑菌浓度（MIC）为2mg/L。在24株mcr-1阳性大肠杆菌中，有17株经重复聚合酶链反应（rep-PCR）证明为非克隆性，这强化了这些菌株来源于环境或动物的假说，并加强了抗菌药物耐药性的“同一健康”背景。
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