Soares Andressa M, Szejnfeld Vera L, Enokihara Mauro Y, Michalany Nílceo, Castro Charlles Hm
Rheumatology Division.
Department of Dermatology.
Eur J Dermatol. 2018 Oct 1;28(5):649-653. doi: 10.1684/ejd.2018.3401.
Sun exposure is critical for vitamin D synthesis and is a major risk factor for the development of non-melanoma skin cancer (NMSC). NMSC is the most common type of cancer in Brazil and coexists with a very high prevalence of vitamin D deficiency.
The present study aimed to assess serum 25-hydroxyvitamin D (25[OH]D) concentration in patients with a recent diagnosis of NMSC.
MATERIALS & METHODS: The serum 25(OH)D concentration of patients with a histological diagnosis of NMSC, made between September 2016 and September 2017, was measured by chemiluminescence up to 60 days after diagnosis and compared to healthy individuals without NMSC matched by age, sex, BMI, and skin phototype.
Forty-one patients with NMSC and 200 healthy controls were evaluated. Most of the patients were men (56.1%) and most had basal cell carcinoma (90.2%). Patients were 67 years old on average (21-87 years) with skin Phototype 2 or 3 (80.6%). Mean serum 25(OH)D concentration in NMSC patients was significantly higher than in healthy controls (p < 0.001). Most of the patients with NMSC (65.9%) had vitamin D deficiency (25[OH]D <30 ng/mL). No association was identified between histological type, time from diagnosis, or a previous history of skin neoplasm and 25(OH)D measurements.
Patients with recently diagnosed NMSC had significantly higher serum levels of 25(OH)D when compared to healthy controls. On the other hand, most of the NMSC patients were still considered to have vitamin D insufficiency.
阳光照射对维生素D的合成至关重要，并且是非黑素瘤皮肤癌（NMSC）发生的主要危险因素。NMSC是巴西最常见的癌症类型，且与维生素D缺乏的高患病率并存。
本研究旨在评估近期诊断为NMSC的患者血清25-羟基维生素D（25[OH]D）浓度。
对2016年9月至2017年9月间经组织学诊断为NMSC的患者，在诊断后60天内通过化学发光法测量其血清25(OH)D浓度，并与年龄、性别、体重指数和皮肤光型相匹配的无NMSC的健康个体进行比较。
评估了41例NMSC患者和200例健康对照。大多数患者为男性（56.1%），大多数患有基底细胞癌（90.2%）。患者平均年龄为67岁（21 - 87岁），皮肤光型为2或3（80.6%）。NMSC患者的平均血清25(OH)D浓度显著高于健康对照（p < 0.001）。大多数NMSC患者（65.9%）存在维生素D缺乏（25[OH]D < 30 ng/mL）。未发现组织学类型、诊断时间或既往皮肤肿瘤病史与25(OH)D测量值之间存在关联。
与健康对照相比，近期诊断为NMSC的患者血清25(OH)D水平显著更高。另一方面，大多数NMSC患者仍被认为存在维生素D不足。
