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本文引用的文献

1
Subthreshold Amyloid Predicts Tau Deposition in Aging.亚阈值淀粉样蛋白可预测衰老中的 Tau 沉积。
J Neurosci. 2018 May 9;38(19):4482-4489. doi: 10.1523/JNEUROSCI.0485-18.2018. Epub 2018 Apr 23.
2
Memory decline accompanies subthreshold amyloid accumulation.记忆衰退伴随着亚阈值淀粉样蛋白积累。
Neurology. 2018 Apr 24;90(17):e1452-e1460. doi: 10.1212/WNL.0000000000005354. Epub 2018 Mar 23.
3
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.TREM2 是 β-淀粉样蛋白的受体,可介导小胶质细胞的功能。
Neuron. 2018 Mar 7;97(5):1023-1031.e7. doi: 10.1016/j.neuron.2018.01.031.
4
Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease.Tau 导致 P301L 转基因小鼠和人类阿尔茨海默病的血管异常和血管生成相关基因表达。
Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1289-E1298. doi: 10.1073/pnas.1710329115. Epub 2018 Jan 22.
5
Why do trials for Alzheimer's disease drugs keep failing? A discontinued drug perspective for 2010-2015.为何阿尔茨海默病药物试验不断失败?2010 - 2015年停用药物视角分析
Expert Opin Investig Drugs. 2017 Jun;26(6):735-739. doi: 10.1080/13543784.2017.1323868.
6
The case for rejecting the amyloid cascade hypothesis.反对淀粉样蛋白级联假说。
Nat Neurosci. 2015 Jun;18(6):794-9. doi: 10.1038/nn.4017.
7
Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation.现有的匹兹堡化合物 B 正电子发射断层扫描阈值过高:统计和病理评估。
Brain. 2015 Jul;138(Pt 7):2020-33. doi: 10.1093/brain/awv112. Epub 2015 May 6.
8
The therapeutics of Alzheimer's disease: where we stand and where we are heading.阿尔茨海默病的治疗学:我们的现状和未来方向。
Ann Neurol. 2013 Sep;74(3):328-36. doi: 10.1002/ana.24001.
9
Neuroinflammation in Alzheimer's disease.阿尔茨海默病中的神经炎症
Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5.
10
Human secreted tau increases amyloid-beta production.人类分泌的tau蛋白会增加β-淀粉样蛋白的产生。
Neurobiol Aging. 2015 Feb;36(2):693-709. doi: 10.1016/j.neurobiolaging.2014.09.007. Epub 2014 Sep 16.

β-Amyloid Accumulation Slows Earlier than Expected in Preclinical Alzheimer's Disease Patients.

作者信息

Camara Henrique, De-Souza Evandro A

机构信息

Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, 13083-862, Campinas, SP, Brazil and.

Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, RJ, Brazil

出版信息

J Neurosci. 2018 Oct 24;38(43):9123-9125. doi: 10.1523/JNEUROSCI.1592-18.2018.

DOI:10.1523/JNEUROSCI.1592-18.2018
PMID:30355622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6705993/
Abstract
摘要