Ravikumar S, Srikumar K
Department of Biological Sciences, Pondicherry University, India.
J Environ Biol. 2005 Jul;26(3):567-9.
Enzymatic and histological change in the testicular cells of rats treated orally and intradermally for 45 days with gibberellic acid (GBA) in independent studies is reported. Assay of hexokinase (HK), acid phosphatase (AcP) and alkaline phosphatase (AkP) in rat testicular tissue homogenate preparations yielded results that suggested changes in these enzyme activities relative to their respective controls. Histological studies showed loss of germ cells, derangement of the germinal cells, and reduction in the size of the seminiferous tubules and dystrophy of Leydig cells. More importantly decreased sperm count in the lumen was observed. A dysregulatory role is thus established for GBA in rat testicular cell function. This compound may serve as an inhibitor of testicular cell function.
据报道，在独立研究中，大鼠经口和皮内用赤霉酸（GBA）处理45天，其睾丸细胞发生了酶学和组织学变化。对大鼠睾丸组织匀浆制剂中的己糖激酶（HK）、酸性磷酸酶（AcP）和碱性磷酸酶（AkP）进行测定，结果表明这些酶活性相对于各自的对照组发生了变化。组织学研究显示生殖细胞丢失、生殖细胞排列紊乱、生精小管尺寸减小以及莱迪希细胞营养不良。更重要的是，观察到管腔内精子数量减少。因此，确定了GBA在大鼠睾丸细胞功能中的失调作用。这种化合物可能作为睾丸细胞功能的抑制剂。
