Jammalamadaka Udayabhanu, Tappa Karthik
Mallinckrodt Institute of Radiology, School of Medicine, Washington University, Saint Louis, MO 63110, USA.
J Funct Biomater. 2018 Mar 1;9(1):22. doi: 10.3390/jfb9010022.
Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering. The applications of 3D printing in the field of regenerative medicine and tissue engineering are limited by the variety of biomaterials that can be used in this technology. Many researchers have developed novel biomaterials and compositions to enable their use in 3D printing methods. The advantages of fabricating scaffolds using 3D printing are numerous, including the ability to create complex geometries, porosities, co-culture of multiple cells, and incorporate growth factors. In this review, recently-developed biomaterials for different tissues are discussed. Biomaterials used in 3D printing are categorized into ceramics, polymers, and composites. Due to the nature of 3D printing methods, most of the ceramics are combined with polymers to enhance their printability. Polymer-based biomaterials are 3D printed mostly using extrusion-based printing and have a broader range of applications in regenerative medicine. The goal of tissue engineering is to fabricate functional and viable organs and, to achieve this, multiple biomaterials and fabrication methods need to be researched.
三维打印作为一种制造方法,在为组织工程创建支架方面具有巨大潜力。三维打印在再生医学和组织工程领域的应用受到该技术可用生物材料种类的限制。许多研究人员开发了新型生物材料和组合物,以使其能够用于三维打印方法。使用三维打印制造支架的优点众多,包括能够创建复杂的几何形状、孔隙率、多种细胞的共培养以及整合生长因子。在本综述中,将讨论最近为不同组织开发的生物材料。用于三维打印的生物材料分为陶瓷、聚合物和复合材料。由于三维打印方法的性质,大多数陶瓷与聚合物结合以提高其可打印性。基于聚合物的生物材料大多使用基于挤出的打印进行三维打印,并且在再生医学中有更广泛的应用。组织工程的目标是制造功能性和有活力的器官,为实现这一目标,需要研究多种生物材料和制造方法。