Takesh Thair, Ho Jessica, Firmalino Miracle Vania, Islip Delaney, Anbarani Afarin, Wilder-Smith Petra
Beckman Laser Institute, University of California, Irvine, CA 92612, USA.
Int J Dent. 2018 Sep 23;2018:2748274. doi: 10.1155/2018/2748274. eCollection 2018.
To identify in patients with dry mouth the effects of a novel test agent (Oral Essentials Hydrating Formula Mouthwash, Beverly Hills, CA) versus a control agent (Biotène Dry Mouth Oral Rinse, GlaxoSmithKline Consumer Healthcare L.P., Moon Township, PA, USA) versus no treatment on dry mouth, plaque, salivary pH and buffering capacity, gingival health, and tooth sensitivity.
In this cross-over study, ten subjects with dry mouth used test and control dry mouth interventions, as well as no dry mouth intervention in randomized sequence. Plaque Index, Gingival Index, Sulcus Bleeding Index, Plaque staining, and photographs were recorded at baseline and end of each study arm. Salivary volume, pH, and buffering capacity were also recorded at these time points. Additionally, subjects completed a questionnaire for dry mouth and dentinal sensitivity at each visit.
Reductions in plaque presence and clinical indices were similar after use of test or control products ( < 0.05). Saliva volume and pH buffering improved significantly after use of test and control products ( < 0.05).
The effects of a novel dry mouth intervention are similar to those of an existing OTC remedy and are significantly better than no intervention.
确定在口干患者中，一种新型测试剂（口腔精华保湿配方漱口水，加利福尼亚州比佛利山庄）与对照剂（百奥泉口干口腔漱口水，葛兰素史克消费者保健有限责任公司，美国宾夕法尼亚州穆恩镇）相比，以及与不进行治疗相比，对口干、牙菌斑、唾液pH值和缓冲能力、牙龈健康及牙齿敏感性的影响。
在这项交叉研究中，10名口干受试者按随机顺序使用测试和对照口干干预措施，以及不进行口干干预。在每个研究阶段的基线和结束时记录菌斑指数、牙龈指数、龈沟出血指数、菌斑染色情况及拍摄照片。在这些时间点还记录唾液量、pH值和缓冲能力。此外，受试者在每次就诊时完成一份关于口干和牙本质敏感的问卷。
使用测试或对照产品后，菌斑存在情况和临床指标的降低情况相似（<0.05）。使用测试和对照产品后，唾液量和pH值缓冲能力显著改善（<0.05）。
一种新型口干干预措施的效果与现有的非处方治疗方法相似，且明显优于不进行干预。
