Ho Jessica, Firmalino Miracle Vania, Anbarani Afarin Golabgir, Takesh Thair, Epstein Joel, Wilder-Smith Petra
Beckman Laser Institute, University of California, Irvine, CA.
Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Health System, Los Angeles, CA.
Dentistry (Sunnyvale). 2017 Feb;7(2). doi: 10.4172/2161-1122.1000411. Epub 2017 Feb 13.
The goal of this study was to identify the effects in patients with hyposalivation of a novel slowly dissolving adhering test disc upon on enamel remineralization, oral biofilm, salivary production, pH and buffering, gingival health, and on self-evaluation of oral well-being.
Five subjects with xerostomia wore custom made retainers carrying 5 demineralized enamel chips for periods of 1 week each. In 1 study arm, subjects used the test agent plus oral hygiene self-care; in the other they used oral hygiene self-care only, with a 1 week washout in between arms. The treatment sequence was randomized. Before and after each study arm Plaque Index (PI), Gingival Index (GI) and Sulcus Bleeding Index (mSBI) were recorded. Clinical plaque staining was quantified using digital image analysis. Saliva production, pH and buffering capacity were recorded. Subjects completed a self-evaluation questionnaire for oral comfort. Enamel samples underwent standardized Knoop microhardness testing to quantify mineralization status.
Plaque presence and clinical Plaque Indices decreased significantly with test agent use (p<0.05). Five-minute saliva production almost doubled 10 and 40 minutes after oral test disc insertion (significant, p<0.05). Salivary pH buffering improved in 4/5 subjects with disc use. All demineralized tooth samples re-hardened intraorally (p>0.05). The discs favorably impacted eating problems and dental sensitivity. Subjects were positive about disc flavor and mouth feel.
Using established techniques, the effects of a novel product in xerostomic patients were evaluated and quantified. The adhering disc facilitated eating, reduced dental sensitivity, improved saliva production and buffering capacity, reduced plaque, and alleviated xerostomia symptoms.
Xerostomia management is challenging. A novel dry mouth disc was effective in alleviating dry mouth symptoms.
本研究的目的是确定一种新型缓释粘附测试盘对唾液分泌减少患者的釉质再矿化、口腔生物膜、唾液分泌、pH值和缓冲能力、牙龈健康以及口腔健康自我评估的影响。
五名患有口干症的受试者佩戴定制的保持器，每个保持器带有5个脱矿釉质片，每次佩戴1周。在一个研究组中，受试者使用测试剂并进行口腔卫生自我护理；在另一个研究组中，他们仅进行口腔卫生自我护理，两组之间有1周的洗脱期。治疗顺序是随机的。在每个研究组前后记录菌斑指数（PI）、牙龈指数（GI）和龈沟出血指数（mSBI）。使用数字图像分析对临床菌斑染色进行定量。记录唾液分泌、pH值和缓冲能力。受试者完成一份口腔舒适度自我评估问卷。对釉质样本进行标准化努氏显微硬度测试以量化矿化状态。
使用测试剂后，菌斑存在和临床菌斑指数显著降低（p<0.05）。插入口腔测试盘10分钟和40分钟后，五分钟唾液分泌量几乎翻倍（显著，p<0.05）。使用测试盘的4/5受试者唾液pH缓冲能力有所改善。所有脱矿牙齿样本在口腔内重新硬化（p>0.05）。测试盘对进食问题和牙齿敏感度有积极影响。受试者对测试盘的味道和口感评价良好。
采用既定技术，对一种新产品在口干症患者中的效果进行了评估和量化。粘附盘便于进食，降低牙齿敏感度，改善唾液分泌和缓冲能力，减少菌斑，并缓解口干症状。
口干症的管理具有挑战性。一种新型口干盘在缓解口干症状方面有效。
