有氧运动训练对女性血清对氧磷酶活性的影响及其与对氧磷酶1-192表型的关系
Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women.
作者信息
Nalcakan Gulbin Rudarli, Varol S Rana, Turgay Faruk, Nalcakan Mesut, Ozkol M Zeki, Karamizrak S Oguz
机构信息
Coaching Education Department, School of Physical Education and Sports, Ege University, Izmir 35100, Turkey.
Esrefpasa Hospital, Izmir 35520, Turkey.
出版信息
J Sport Health Sci. 2016 Dec;5(4):462-468. doi: 10.1016/j.jshs.2015.01.010. Epub 2015 May 28.
BACKGROUND
Paraoxonase 1 (PON1) is an antioxidant enzyme that protects high-density lipoprotein (HDL) and low-density lipoprotein against oxidation. Limited studies have addressed the influence of exercise on PON1 activity and its relationship with PON1 phenotypes. We investigated relationships between PON1-192 phenotypes, PON1 activity, aerobic exercise, and blood lipid and lipoprotein concentrations in middle-aged women.
METHODS
An exercise group ( = 50) engaging in regular aerobic exercise and a control group ( = 41) were selected from a subset of 300 Caucasian women that met the inclusion criteria. Serum PON1, salt-stimulated PON1 (SSPON1), and arylesterase (ARE) activities; cholesterol levels and ARE activities of total HDL and HDL subgroups (HDLs) (supernatants obtained by polyethylene glycol); and blood lipid and lipoprotein concentrations were determined by standardized enzymatic methods. PON1-192 QQ (low activity), QR (moderate activity), and RR (high activity) phenotype groups were defined using serum SSPON1/ARE activity ratios. The R-carries (RC) phenotype group consisted of the QR and RR groups combined.
RESULTS
All lipid and lipoprotein concentrations were greater in the exercise group than in the control group. Regardless of phenotype, no significant differences were observed between the exercise and control groups in terms of serum PON1, SSPON1, or ARE activity associated with HDLs ( > 0.05), whereas PON1 activities in QQ-phenotyped women in the exercise group were significantly higher than those in the control group ( < 0.01), but not the RC group. A statistically significant interaction between PON1 phenotypes (QQ and RC groups) and exercise (exercise and control groups) on PON1 activity was found.
CONCLUSION
These results showed that a regular aerobic exercise program can improve PON1 activity depending on PON1-192 phenotype, but not on lipid and lipoprotein levels, in middle-aged Turkish women.
背景
对氧磷酶1（PON1）是一种抗氧化酶，可保护高密度脂蛋白（HDL）和低密度脂蛋白免受氧化。关于运动对PON1活性的影响及其与PON1表型的关系的研究有限。我们调查了中年女性中PON1-192表型、PON1活性、有氧运动以及血脂和脂蛋白浓度之间的关系。
方法
从300名符合纳入标准的白种女性子集中选取一个进行定期有氧运动的运动组（n = 50）和一个对照组（n = 41）。采用标准化酶法测定血清PON1、盐刺激的PON1（SSPON1）和芳基酯酶（ARE）活性；总HDL和HDL亚组（HDLs）（通过聚乙二醇获得的上清液）的胆固醇水平和ARE活性；以及血脂和脂蛋白浓度。使用血清SSPON1/ARE活性比值定义PON1-192 QQ（低活性）、QR（中等活性）和RR（高活性）表型组。R携带者（RC）表型组由QR和RR组合而成。
结果
运动组的所有血脂和脂蛋白浓度均高于对照组。无论表型如何，运动组和对照组在与HDLs相关的血清PON1、SSPON1或ARE活性方面均未观察到显著差异（P>0.05），而运动组中QQ表型女性的PON1活性显著高于对照组（P<0.01），但RC组并非如此。发现PON1表型（QQ和RC组）与运动（运动组和对照组）之间在PON1活性上存在统计学显著的相互作用。
结论
这些结果表明，在中年土耳其女性中，定期有氧运动计划可根据PON1-192表型改善PON1活性，但对血脂和脂蛋白水平无影响。
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