Selroos O, Klockars M
Sarcoidosis. 1987 Mar;4(1):13-7.
We measured angiotensin converting enzyme (ACE) and beta2-microglobulin (beta 2M) in the serum of 107 patients with sarcoidosis in different clinical stages and in healthy subjects. In patients with acute sarcoidosis and erythema nodosum (EN) we found increased beta 2M values but low ACE activity. Patients with newly-detected sarcoidosis but without EN had increased ACE activity; however, their beta 2M-levels were normal or only slightly elevated. Patients with chronic active sarcoidosis had high ACE activity; however, their beta 2M-levels were normal in a stable phase, but significantly increased during clinical relapses. Patients with resolved sarcoidosis had normal ACE and beta 2M values. The results indicate that serum beta 2M concentrations are increased in connection with new granuloma formation-i.e. lymphocytic activation-whereas the serum ACE activity increases later on when active granulomas have been formed. In sarcoidosis, simultaneous determinations of serum ACE and beta 2M may be useful for describing the stage of the disease. The correlation between ACE and beta 2M will also be different, depending on the composition of the clinical series of sarcoidosis patients.
我们检测了107例不同临床阶段的结节病患者以及健康受试者血清中的血管紧张素转换酶（ACE）和β2-微球蛋白（β2M）。在急性结节病和结节性红斑（EN）患者中，我们发现β2M值升高但ACE活性降低。新发现的无EN的结节病患者ACE活性升高；然而，他们的β2M水平正常或仅略有升高。慢性活动性结节病患者ACE活性高；然而，他们的β2M水平在稳定期正常，但在临床复发期间显著升高。结节病已缓解的患者ACE和β2M值正常。结果表明，血清β2M浓度与新的肉芽肿形成即淋巴细胞活化有关而升高，而血清ACE活性在活性肉芽肿形成后升高。在结节病中，同时测定血清ACE和β2M可能有助于描述疾病阶段。ACE和β2M之间的相关性也会因结节病患者临床系列的组成不同而有所差异。
