Larzul J J, Le Treut A, Couliou H, Beaumont D, Delaval P, Sapene M, de Labarthe B
Nouv Presse Med. 1981 Feb 28;10(9):675-8.
Serum levels of angiotensin-converting enzyme (ACE) were measured in 111 healthy subjects and in 117 adult patients with mediastinal and pulmonary sarcoidosis. The patients were followed up for 3 years. Detailed clinical investigations and ACE level measurements were performed every three months. The activity of the disease was assessed in 94 patients without treatment and in 23 patients under corticosteroid therapy. Mean ACE levels were significantly higher (p less than 0,0001) in all patients with sarcoidosis than in controls. They were also high (greater than 35 units/ml) in 32 patients with active forms of the disease. In 19 patients with inactive forms ACE levels were either moderately raised on normal, while considerable variations were observed in those with stable, persistent sarcoidosis. Complete spontaneous or therapeutically induced remission were accompanied by a return of ACE to normal values, but this was not the case for incomplete remission. There was no correlation between ACE levels and the radiological stages of the disease. Measuring ACE levels in patients with sarcoidosis may therefore contribute to diagnosis and surveillance and help to distinguish between complete and incomplete remissions.
对111名健康受试者以及117名患有纵隔和肺部结节病的成年患者测定了血清血管紧张素转换酶（ACE）水平。对这些患者进行了3年的随访。每三个月进行详细的临床检查和ACE水平测量。对94名未接受治疗的患者和23名接受皮质类固醇治疗的患者的疾病活动情况进行了评估。所有结节病患者的平均ACE水平显著高于对照组（p＜0.0001）。32名患有活动性疾病的患者的ACE水平也很高（＞35单位/毫升）。19名患有非活动性疾病的患者的ACE水平要么中度升高要么正常，而在患有稳定、持续性结节病的患者中观察到了相当大的差异。完全自发缓解或治疗诱导缓解伴随着ACE恢复到正常水平，但不完全缓解的情况并非如此。ACE水平与疾病的放射学分期之间没有相关性。因此，测量结节病患者的ACE水平可能有助于诊断和监测，并有助于区分完全缓解和不完全缓解。
