Grönhagen-Riska C, Selroos O, Wägar G, Fyhrquist F
Scand J Respir Dis. 1979 Apr;60(2):94-101.
Serum angiotensin-converting enzyme (ACE) was studied in 51 patients with early or newly diagnosed sarcoidosis. Only 45% of these patients had increased ACE activity when their diagnosis was established, which diminishes the diagnostic value of this enzyme measurement. On the other hand, ACE accurately reflected disease activity, and it proved a useful tool for assessing of need for corticosteroid treatment. Patients with acute sarcoidosis associated with erythema nodosum (EN) had low ACE activity compared with the other patients with active, but less acute disease. Serum ACE was not significantly correlated with blood lymphocytes or the immunoglobulins, but there was a positive correlation between the enzyme and serum lysozyme, which strengthens the hypothesis of both enzymes being produced by the epithelioid cells of sarcoid granulomas.
对51例早期或新诊断的结节病患者的血清血管紧张素转换酶（ACE）进行了研究。在确诊时，这些患者中只有45%的ACE活性升高，这降低了该酶检测的诊断价值。另一方面，ACE准确反映了疾病活动情况，并且证明是评估是否需要皮质类固醇治疗的有用工具。与其他活动性但病情不太急性的患者相比，伴有结节性红斑（EN）的急性结节病患者的ACE活性较低。血清ACE与血液淋巴细胞或免疫球蛋白无显著相关性，但该酶与血清溶菌酶呈正相关，这强化了两种酶均由结节病肉芽肿的上皮样细胞产生的假说。
