Su Xiaojuan, Huang Lingyi, Xiao Dongqiong, Qu Yi, Mu Dezhi
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.
Front Neurosci. 2018 Oct 9;12:697. doi: 10.3389/fnins.2018.00697. eCollection 2018.
Activin A belongs to the transforming growth factor superfamily and has a variety of biological functions. Studies have revealed that activin A can regulate the body's immune and inflammatory responses and participate in the regulation of cell death. In addition, activin A also has neurotrophic function and plays an important role in the repair of brain damage. This article summarizes recent advances in understanding the role and mechanism of action of activin A in brain injury and provides new hints into the application of activin A in the treatment of brain injury.
激活素A属于转化生长因子超家族，具有多种生物学功能。研究表明，激活素A可调节机体的免疫和炎症反应，并参与细胞死亡的调控。此外，激活素A还具有神经营养功能，在脑损伤修复中发挥重要作用。本文综述了近年来对激活素A在脑损伤中的作用及作用机制的认识进展，并为激活素A在脑损伤治疗中的应用提供了新的线索。
