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[蛋白水解抑制剂对缺血后毒血症中血清蛋白酶活性及其抗胰蛋白酶活性的影响]

[Effect of proteolysis inhibitors on serum proteinase activity and its antitryptic activity in postischemic toxemia].

作者信息

Protsenko V A, Kharchenko V Z, Veselov V F, Spitsyn I F, Bogadel'nikov I V

出版信息

Farmakol Toksikol. 1978 Nov-Dec;41(6):693-6.

PMID:720581
Abstract

Parenteral administration to animals of the antikallikrein serum containing 200gamma/ml of antibodies to the pancreatic kallikrein (10 ml/kg), ingitryl (1.5 Un/kg) and of tracilol (10 000 Un/kg) exerts in post-ischemic toxemia an inhibiting effect on the protamine-splitting blood serum activity and does not affect the benzoylarginine-paranitroanilide rate of splitting. Changes of the blood serum ability to bind trypsin and manifestation of the protamine-splitting activity during the first 9 hours of observation are of an undulating nature and the changes of these characteristics are reciprocal.

摘要

给动物静脉注射含200γ/ml抗胰激肽抗体的抗激肽血清(10 ml/kg)、英吉利(1.5单位/kg)和抑肽酶(10000单位/kg),对缺血后毒血症中鱼精蛋白分解血清活性有抑制作用,且不影响苯甲酰精氨酸-对硝基苯胺的分解速率。在观察的前9小时内,血清结合胰蛋白酶能力的变化和鱼精蛋白分解活性的表现呈波动性质,且这些特征的变化是相互的。

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1
[Effect of proteolysis inhibitors on serum proteinase activity and its antitryptic activity in postischemic toxemia].[蛋白水解抑制剂对缺血后毒血症中血清蛋白酶活性及其抗胰蛋白酶活性的影响]
Farmakol Toksikol. 1978 Nov-Dec;41(6):693-6.
2
[Effect of pancreatic kallikrein and trypsin inhibitors on the course of postischemic toxemia].[胰激肽释放酶和胰蛋白酶抑制剂对缺血后毒血症病程的影响]
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