Department of Epidemiology, University of North Carolina, Gillings School of Global Public Health, 2101 McGavran-Greenberg Hall, 135 Dauer Drive, Chapel Hill, NC, 27599, USA.
Department of Health Behavior, University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC, USA.
AIDS Behav. 2019 Mar;23(3):609-616. doi: 10.1007/s10461-018-2318-8.
People who inject drugs (PWID) with HIV experience an elevated risk of death. A potentially important determinant of survival is the high burden of depression. This study examined the relationship of depressive symptoms at HIV testing with 2-year all-cause mortality among newly diagnosed HIV-positive PWID in Vietnam. At HIV testing, 141 PWID (42%) experienced severe depressive symptoms, and over the 2 years following diagnosis, 82 PWID (24%) died. Controlling for potential confounders, the 2-year risk of death among those with depressive symptoms was 9.7% (95% CI - 1.2, 20.6%) higher than the risk among those without depressive symptoms. This increased risk of mortality for PWID with depressive symptoms was relatively consistent throughout the 2-year period: at 6, 12, and 18 months, the risk difference was 12.6% (5.5-19.7%), 13.9% (4.6-23.2%), and 11.0% (0.9-21.1%), respectively. HIV diagnosis may provide an important opportunity for depression screening and treatment, subsequently improving survival in this key population.Trial registry: ClinicalTrials.gov NCT01689545.
HIV 感染者（PWID）的死亡风险较高。抑郁是一个潜在的重要决定因素。本研究旨在探讨越南新诊断 HIV 阳性 PWID 在 HIV 检测时的抑郁症状与 2 年全因死亡率之间的关系。在 HIV 检测时，141 名 PWID（42%）出现严重抑郁症状，在诊断后的 2 年内，82 名 PWID（24%）死亡。在控制潜在混杂因素后，有抑郁症状的患者在 2 年内的死亡风险比无抑郁症状的患者高 9.7%（95%CI-1.2，20.6%）。在整个 2 年期间，PWID 抑郁症状与较高死亡率之间的相关性相对一致：在 6、12 和 18 个月时，风险差异分别为 12.6%（5.5-19.7%）、13.9%（4.6-23.2%）和 11.0%（0.9-21.1%）。HIV 诊断可能为抑郁筛查和治疗提供重要机会，从而改善该关键人群的生存。试验注册：ClinicalTrials.gov NCT01689545。
