Oral Pathology Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Dental Biomaterials Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
J Prosthodont. 2019 Jun;28(5):519-525. doi: 10.1111/jopr.12993. Epub 2018 Nov 14.
To evaluate marginal bone loss (MBL) of dental implants inserted in active lichen planus patients.
The study included 59 subjects divided into 3 groups depending on their lichen planus diagnosis and administration of a low dose of corticosteroids: 17 healthy individuals, 20 controlled lichen planus patients controlled using low doses of systemic corticosteroids, and 22 noncontrolled lichen planus patients. During 4-year follow-up sessions MBL was evaluated, and biopsies were collected from lichen planus patients and examined. Two-way ANOVA was used to analyze the data (α = 0.05).
There was no statistically significant difference in MBL between healthy and controlled patients; however, noncontrolled patients exhibited increased MBL (F = 1309, p < 0.001) which reached 2.53 mm after 4 years. There were significant interactions between state of the disease (F = 1309, p < 0.001), evaluation time (F = 317, p < 0.001), and interaction between state of the disease and observation time (F = 159, p < 0.001). Histopathologic examination of collected biopsies revealed healthy tissue architecture of the controlled patients, while inflammatory cellular infiltration and signs of classical destructive tissue were observed for noncontrolled patients.
Lichen planus patients receiving dental implants should be controlled on a low-dose of corticosteroids to prevent accelerated MBL and to reduce remission of clinical manifestations.
评估患有活动性扁平苔藓患者中植入牙种植体的边缘骨丧失（MBL）情况。
该研究共纳入 59 名受试者，根据其扁平苔藓诊断和低剂量皮质类固醇的使用情况分为 3 组：17 名健康个体、20 名使用低剂量全身皮质类固醇控制的扁平苔藓患者和 22 名未控制的扁平苔藓患者。在 4 年的随访期间，评估了 MBL，并从扁平苔藓患者中采集活检组织进行检查。采用双向方差分析（α=0.05）进行数据分析。
健康患者和控制患者之间的 MBL 无统计学差异；然而，未控制患者的 MBL 增加（F=1309，p<0.001），4 年后达到 2.53 毫米。疾病状态（F=1309，p<0.001）、评估时间（F=317，p<0.001）以及疾病状态和观察时间之间的相互作用（F=159，p<0.001）之间存在显著交互作用。对采集的活检组织进行组织病理学检查发现，控制患者的组织具有健康的组织结构，而未控制患者则观察到炎症细胞浸润和经典破坏性组织的迹象。
接受牙种植体治疗的扁平苔藓患者应接受低剂量皮质类固醇治疗以预防加速的 MBL 并减少临床表现的缓解。
