Institute of Botany, University of Cologne, Zülpicherstr 47b, 50674, Cologne, Germany.
Am J Bot. 2018 Nov;105(11):1788-1791. doi: 10.1002/ajb2.1180. Epub 2018 Oct 25.
Understanding the molecular mechanisms that allow phenotypic diversification in response to natural or artificial selection is one of the major challenges of modern biology (Barrett and Hoekstra, 2011). The evolution of gene regulation is a prominent pillar for adaptation in sessile organisms like plants because the activity of genes must be tuned to the environment. Today, we can accurately document the genome-wide distribution of -regulatory variants. Here, I summarize how current data show that both positive selection and purifying selection contribute to shape -regulatory variation. To disentangle their relative impact, I argue that -regulatory and amino-acid evolutionary rates should be analyzed jointly.
理解分子机制,使表型多样化以适应自然或人为选择,是现代生物学的主要挑战之一(Barrett 和 Hoekstra,2011)。基因调控的进化是植物等固着生物适应的重要支柱,因为基因的活性必须适应环境。如今,我们可以准确地记录基因组范围内 -调控变体的分布。在这里,我总结了当前的数据如何表明,正选择和净化选择都有助于塑造 -调控变异。为了理清它们的相对影响,我认为应该联合分析 -调控和氨基酸进化速率。